Detailed information of TA system TA117381

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3352438..3352954
• Replicon: chromosome
• Accession: NZ_CP035207
• Organism: Klebsiella quasipneumoniae strain TH114

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EQH50_RS16300
• Protein ID: WP_152651597.1
• Coordinates: 3352438..3352722 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: EQH50_RS16305
• Protein ID: WP_002886901.1
• Coordinates: 3352712..3352954 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQH50_RS16285	3347483..3349138	+	1656	WP_152651595.1	alpha,alpha-phosphotrehalase	-
EQH50_RS16290	3349524..3351662	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
EQH50_RS16295	3351970..3352434	+	465	WP_152651596.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
EQH50_RS16300	3352438..3352722	-	285	WP_152651597.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EQH50_RS16305	3352712..3352954	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EQH50_RS16310	3353032..3354942	-	1911	WP_004206509.1	BglG family transcription antiterminator	-
EQH50_RS16315	3354965..3356116	-	1152	WP_130939669.1	lactonase family protein	-
EQH50_RS16320	3356183..3356923	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11169.02 Da
• Isoelectric Point: 10.3787

>T117381 WP_152651597.1 NZ_CP035207:c3352722-3352438 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESARLNDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T117381 NZ_CP035207:c3352722-3352438 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCTTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAACGATTTGCCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT117381 WP_002886901.1 NZ_CP035207:c3352954-3352712 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT117381 NZ_CP035207:c3352954-3352712 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGGCTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0