Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 415383..416040 Replicon chromosome
Accession NZ_CP035202
Organism Klebsiella pneumoniae strain LH94

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag EQH49_RS02100 Protein ID WP_002916310.1
Coordinates 415383..415793 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag EQH49_RS02105 Protein ID WP_002916312.1
Coordinates 415774..416040 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH49_RS02080 411383..413116 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
EQH49_RS02085 413122..413835 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EQH49_RS02090 413858..414754 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
EQH49_RS02095 414855..415376 + 522 WP_004144730.1 flavodoxin FldB -
EQH49_RS02100 415383..415793 - 411 WP_002916310.1 protein YgfX Toxin
EQH49_RS02105 415774..416040 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
EQH49_RS02110 416286..417269 + 984 WP_064145188.1 tRNA-modifying protein YgfZ -
EQH49_RS02115 417420..418079 - 660 WP_002916317.1 hemolysin III family protein -
EQH49_RS02120 418243..418554 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
EQH49_RS02125 418604..419332 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
EQH49_RS02130 419451..420884 + 1434 WP_064145187.1 6-phospho-beta-glucosidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T117348 WP_002916310.1 NZ_CP035202:c415793-415383 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T117348 NZ_CP035202:c415793-415383 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT117348 WP_002916312.1 NZ_CP035202:c416040-415774 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT117348 NZ_CP035202:c416040-415774 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References