Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3301517..3302033 Replicon chromosome
Accession NZ_CP035194
Organism Klebsiella pneumoniae strain LH102-A

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag EPO92_RS16400 Protein ID WP_004178374.1
Coordinates 3301749..3302033 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag EPO92_RS16395 Protein ID WP_002886901.1
Coordinates 3301517..3301759 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPO92_RS16380 3297545..3298285 + 741 WP_083565046.1 KDGP aldolase family protein -
EPO92_RS16385 3298352..3299506 + 1155 WP_002886900.1 lactonase family protein -
EPO92_RS16390 3299529..3301439 + 1911 WP_009486549.1 BglG family transcription antiterminator -
EPO92_RS16395 3301517..3301759 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EPO92_RS16400 3301749..3302033 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EPO92_RS16405 3302037..3302501 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
EPO92_RS16410 3302830..3304968 - 2139 WP_032415880.1 anaerobic ribonucleoside-triphosphate reductase -
EPO92_RS16415 3305325..3306068 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
EPO92_RS25835 3306071..3306244 - 174 WP_004222159.1 hypothetical protein -
EPO92_RS16420 3306329..3306637 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T117324 WP_004178374.1 NZ_CP035194:3301749-3302033 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T117324 NZ_CP035194:3301749-3302033 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT117324 WP_002886901.1 NZ_CP035194:3301517-3301759 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT117324 NZ_CP035194:3301517-3301759 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCTGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References