Detailed information of TA system TA117299

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1549534..1550213
• Replicon: chromosome
• Accession: NZ_CP035185
• Organism: Acinetobacter baumannii strain 11A1213CRGN055

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: EQ842_RS07390
• Protein ID: WP_000838146.1
• Coordinates: 1549534..1549716 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: EQ842_RS07395
• Protein ID: WP_000966688.1
• Coordinates: 1549809..1550213 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQ842_RS07345	1544607..1545011	+	405	WP_000247948.1	hypothetical protein	-
EQ842_RS07350	1544983..1545351	+	369	WP_002055488.1	hypothetical protein	-
EQ842_RS07355	1545353..1545751	+	399	WP_001251850.1	hypothetical protein	-
EQ842_RS07360	1545753..1545971	+	219	WP_001277687.1	hypothetical protein	-
EQ842_RS07365	1546065..1546418	+	354	WP_000064599.1	hypothetical protein	-
EQ842_RS07370	1546418..1547653	+	1236	WP_000002422.1	hypothetical protein	-
EQ842_RS07375	1547706..1548623	+	918	WP_000094250.1	hypothetical protein	-
EQ842_RS07380	1548693..1549208	+	516	WP_001185608.1	hypothetical protein	-
EQ842_RS07390	1549534..1549716	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
EQ842_RS07395	1549809..1550213	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EQ842_RS07400	1550312..1550488	+	177	WP_014466185.1	hypothetical protein	-
EQ842_RS07405	1550497..1550820	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
EQ842_RS07410	1550852..1551646	+	795	WP_000720608.1	hypothetical protein	-
EQ842_RS07415	1551695..1551934	-	240	WP_000763623.1	Arc family DNA-binding protein	-
EQ842_RS07420	1552057..1552212	+	156	WP_001103649.1	Arc family DNA-binding protein	-
EQ842_RS07425	1552209..1553201	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1516896..1577398	60502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T117299 WP_000838146.1 NZ_CP035185:1549534-1549716 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T117299 NZ_CP035185:1549534-1549716 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT117299 WP_000966688.1 NZ_CP035185:1549809-1550213 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT117299 NZ_CP035185:1549809-1550213 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6