Detailed information of TA system TA117297

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1549425..1550104
• Replicon: chromosome
• Accession: NZ_CP035184
• Organism: Acinetobacter baumannii strain 11A1314CRGN088

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: EQ843_RS07425
• Protein ID: WP_000838146.1
• Coordinates: 1549425..1549607 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: EQ843_RS07430
• Protein ID: WP_000966688.1
• Coordinates: 1549700..1550104 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQ843_RS07380	1544498..1544902	+	405	WP_000247948.1	hypothetical protein	-
EQ843_RS07385	1544874..1545242	+	369	WP_002055488.1	hypothetical protein	-
EQ843_RS07390	1545244..1545642	+	399	WP_001251850.1	hypothetical protein	-
EQ843_RS07395	1545644..1545862	+	219	WP_001277687.1	hypothetical protein	-
EQ843_RS07400	1545956..1546309	+	354	WP_000064599.1	hypothetical protein	-
EQ843_RS07405	1546309..1547544	+	1236	WP_000002422.1	hypothetical protein	-
EQ843_RS07410	1547597..1548514	+	918	WP_000094250.1	hypothetical protein	-
EQ843_RS07415	1548584..1549099	+	516	WP_001185608.1	hypothetical protein	-
EQ843_RS07425	1549425..1549607	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
EQ843_RS07430	1549700..1550104	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EQ843_RS07435	1550203..1550379	+	177	WP_014466185.1	hypothetical protein	-
EQ843_RS07440	1550388..1550711	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
EQ843_RS07445	1550743..1551537	+	795	WP_000720608.1	hypothetical protein	-
EQ843_RS07450	1551586..1551825	-	240	WP_000763623.1	Arc family DNA-binding protein	-
EQ843_RS07455	1551948..1552103	+	156	WP_001103649.1	Arc family DNA-binding protein	-
EQ843_RS07460	1552100..1553092	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1516787..1577289	60502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T117297 WP_000838146.1 NZ_CP035184:1549425-1549607 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T117297 NZ_CP035184:1549425-1549607 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT117297 WP_000966688.1 NZ_CP035184:1549700-1550104 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT117297 NZ_CP035184:1549700-1550104 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6