Detailed information of TA system TA117295

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1553356..1554035
• Replicon: chromosome
• Accession: NZ_CP035183
• Organism: Acinetobacter baumannii strain 11A14CRGN003

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: EQ844_RS07450
• Protein ID: WP_000838146.1
• Coordinates: 1553356..1553538 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: EQ844_RS07455
• Protein ID: WP_000966688.1
• Coordinates: 1553631..1554035 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQ844_RS07405	1548429..1548833	+	405	WP_000247948.1	hypothetical protein	-
EQ844_RS07410	1548805..1549173	+	369	WP_002055488.1	hypothetical protein	-
EQ844_RS07415	1549175..1549573	+	399	WP_001251850.1	hypothetical protein	-
EQ844_RS07420	1549575..1549793	+	219	WP_001277687.1	hypothetical protein	-
EQ844_RS07425	1549887..1550240	+	354	WP_000064599.1	hypothetical protein	-
EQ844_RS07430	1550240..1551475	+	1236	WP_000002422.1	hypothetical protein	-
EQ844_RS07435	1551528..1552445	+	918	WP_000094250.1	hypothetical protein	-
EQ844_RS07440	1552515..1553030	+	516	WP_001185608.1	hypothetical protein	-
EQ844_RS07450	1553356..1553538	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
EQ844_RS07455	1553631..1554035	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EQ844_RS07460	1554134..1554310	+	177	WP_014466185.1	hypothetical protein	-
EQ844_RS07465	1554319..1554642	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
EQ844_RS07470	1554674..1555468	+	795	WP_000720608.1	hypothetical protein	-
EQ844_RS07475	1555517..1555756	-	240	WP_000763623.1	Arc family DNA-binding protein	-
EQ844_RS07480	1555879..1556034	+	156	WP_001103649.1	Arc family DNA-binding protein	-
EQ844_RS07485	1556031..1557023	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1522082..1577322	55240

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T117295 WP_000838146.1 NZ_CP035183:1553356-1553538 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T117295 NZ_CP035183:1553356-1553538 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT117295 WP_000966688.1 NZ_CP035183:1553631-1554035 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT117295 NZ_CP035183:1553631-1554035 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6