Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1125213..1125706 Replicon chromosome
Accession NZ_CP035136
Organism Enterococcus faecium strain SRCM103341

Toxin (Protein)


Gene name relE Uniprot ID A0A133MTG0
Locus tag EQI29_RS05860 Protein ID WP_002329323.1
Coordinates 1125440..1125706 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829AAJ0
Locus tag EQI29_RS05855 Protein ID WP_002329324.1
Coordinates 1125213..1125443 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQI29_RS05815 1120221..1120988 + 768 Protein_1093 MurR/RpiR family transcriptional regulator -
EQI29_RS05820 1120989..1121431 + 443 Protein_1094 hypothetical protein -
EQI29_RS05825 1121641..1122231 - 591 WP_002329329.1 glutamine amidotransferase -
EQI29_RS05830 1122962..1123921 + 960 WP_002336308.1 IS30 family transposase -
EQI29_RS05835 1124084..1124389 + 306 WP_002329327.1 hypothetical protein -
EQI29_RS05840 1124402..1124737 + 336 WP_002329326.1 hypothetical protein -
EQI29_RS05855 1125213..1125443 + 231 WP_002329324.1 hypothetical protein Antitoxin
EQI29_RS05860 1125440..1125706 + 267 WP_002329323.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQI29_RS05865 1125958..1126185 + 228 WP_002329322.1 hypothetical protein -
EQI29_RS05870 1126201..1127367 + 1167 WP_002329321.1 oxygen-independent coproporphyrinogen III oxidase -
EQI29_RS05875 1127600..1128643 + 1044 WP_128440475.1 heat-inducible transcriptional repressor HrcA -
EQI29_RS05880 1128737..1129300 + 564 WP_002292135.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10617.27 Da        Isoelectric Point: 10.1925

>T117251 WP_002329323.1 NZ_CP035136:1125440-1125706 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDDQMVVIAIQV
GHRRNIYD

Download         Length: 267 bp

>T117251 NZ_CP035136:1125440-1125706 [Enterococcus faecium]
ATGACCTACCGTTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAGCATCAAGCGACGCTGATTGT
TCGATGGCTGTATCAACATATTGATGGTATTGACGATCCGAGAAAATTCGGAAAAGGATTGACCGCTAATCGTTCAGGAC
AATGGCGTTATCGAATTGGCAAATATCGTGTGTTGGTAGAGATAGAAGATGATCAAATGGTTGTTATCGCTATTCAAGTG
GGACACCGAAGAAATATCTATGATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8863.97 Da        Isoelectric Point: 4.1938

>AT117251 WP_002329324.1 NZ_CP035136:1125213-1125443 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Download         Length: 231 bp

>AT117251 NZ_CP035136:1125213-1125443 [Enterococcus faecium]
ATGGCTATGATTACGGTTCGTGTGAGTGATGCCGAAAAAGAATGGCTTTCTTATATGGCGGAATTTTATGGGATTACTTT
ATCTGAGCTTCTAAAAACCTATTCGATGGAACAACTAGAAGATGAATACGATCGTCAAACGGCTGAAATTGCCCATAAAC
ATTGGGTAGAAAGTGGAAAAACAACAGTATCCATGGAAGAAATCCTTCATGAATTTGGAGGGCTGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133MTG0

Antitoxin

Source ID Structure
AlphaFold DB A0A829AAJ0

References