Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4376777..4377362 Replicon chromosome
Accession NZ_CP035129
Organism Kosakonia cowanii strain FBS 223

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag EQG67_RS20640 Protein ID WP_128483861.1
Coordinates 4376777..4377067 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag EQG67_RS20645 Protein ID WP_042712602.1
Coordinates 4377084..4377362 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQG67_RS20620 4372568..4374154 + 1587 WP_128483858.1 RNA repair transcriptional activator RtcR -
EQG67_RS20625 4374304..4375245 + 942 WP_128483859.1 ketopantoate/pantoate/pantothenate transporter PanS -
EQG67_RS20630 4375394..4375666 + 273 WP_042712605.1 DUF3811 domain-containing protein -
EQG67_RS20635 4375667..4376536 - 870 WP_128483860.1 23S rRNA pseudouridine(2604) synthase RluF -
EQG67_RS20640 4376777..4377067 + 291 WP_128483861.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQG67_RS20645 4377084..4377362 + 279 WP_042712602.1 putative addiction module antidote protein Antitoxin
EQG67_RS20650 4377391..4379022 - 1632 WP_128483862.1 Na/Pi cotransporter family protein -
EQG67_RS20655 4379210..4379677 - 468 WP_076770277.1 hypothetical protein -
EQG67_RS20660 4379661..4380437 - 777 WP_128484121.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(28-82)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10719.56 Da        Isoelectric Point: 9.9480

>T117249 WP_128483861.1 NZ_CP035129:4376777-4377067 [Kosakonia cowanii]
MKEIVQTDAFKLWESSLRDAKLRAIISARLFRLANGLTGDVKPVGEGISELRIHYGAGYRIYFQLRGNTVVVLLCGGDKS
TQPKDIIYAKYLAKCV

Download         Length: 291 bp

>T117249 NZ_CP035129:4376777-4377067 [Kosakonia cowanii]
ATGAAAGAGATAGTCCAAACCGACGCGTTTAAACTCTGGGAGTCATCATTACGCGATGCGAAATTGCGAGCGATTATCTC
AGCGCGTCTTTTTAGATTGGCAAATGGCCTCACCGGAGATGTGAAACCAGTCGGGGAAGGGATAAGCGAATTACGAATAC
ATTATGGTGCCGGTTACCGCATCTATTTCCAGCTGCGGGGTAATACCGTTGTCGTGTTGTTGTGTGGGGGGGATAAAAGT
ACCCAACCAAAAGACATTATCTACGCCAAATATCTGGCAAAATGTGTTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9818.36 Da        Isoelectric Point: 6.2978

>AT117249 WP_042712602.1 NZ_CP035129:4377084-4377362 [Kosakonia cowanii]
MNKLTPYDPAAALVNDEAIALFMADALETGDAAYIARALGVIARAKGMSDIAAETGLSREQLYRSFSEKGNPTLKTTLSV
MKALGIELTVKR

Download         Length: 279 bp

>AT117249 NZ_CP035129:4377084-4377362 [Kosakonia cowanii]
ATGAATAAATTAACCCCTTATGATCCCGCAGCGGCACTGGTTAACGATGAGGCGATAGCGCTCTTCATGGCGGATGCACT
GGAAACCGGCGATGCGGCTTATATCGCCCGAGCATTAGGGGTGATCGCTCGGGCCAAAGGGATGAGCGACATCGCTGCAG
AAACCGGTTTGTCACGCGAGCAGCTCTATCGCTCTTTCAGCGAAAAGGGGAATCCGACACTGAAGACGACACTCTCCGTA
ATGAAAGCGCTGGGCATTGAACTGACAGTCAAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References