Detailed information of TA system TA117248

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4136017..4136533
• Replicon: chromosome
• Accession: NZ_CP035129
• Organism: Kosakonia cowanii strain FBS 223

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EQG67_RS19525
• Protein ID: WP_128483767.1
• Coordinates: 4136017..4136301 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EQG67_RS19530
• Protein ID: WP_042714051.1
• Coordinates: 4136291..4136533 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQG67_RS19510	4131999..4132943	+	945	WP_128483765.1	trehalose operon repressor TreR	-
EQG67_RS19515	4133291..4135426	+	2136	WP_128483766.1	anaerobic ribonucleoside-triphosphate reductase	-
EQG67_RS19520	4135547..4136011	+	465	WP_042714081.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
EQG67_RS19525	4136017..4136301	-	285	WP_128483767.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EQG67_RS19530	4136291..4136533	-	243	WP_042714051.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EQG67_RS19535	4136612..4138522	-	1911	WP_128483768.1	BglG family transcription antiterminator	-
EQG67_RS19540	4138606..4139343	-	738	WP_042714055.1	KDGP aldolase family protein	-
EQG67_RS19545	4139340..4140458	-	1119	WP_128483769.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10936.95 Da
• Isoelectric Point: 10.5826

>T117248 WP_128483767.1 NZ_CP035129:c4136301-4136017 [Kosakonia cowanii]
MIYELVFDPRALKEWKKLGVTVQAQFKKKLAEVLVQPRVEKARLHGLPDCYKIKLRASGYRLIYQVRDNVVTVFVVAIGK
REKEAAYHSANHRL

Nucleotide

• Length: 285 bp

>T117248 NZ_CP035129:c4136301-4136017 [Kosakonia cowanii]
ATGATCTATGAGCTGGTGTTTGATCCGCGCGCGTTGAAAGAGTGGAAAAAACTGGGCGTGACGGTTCAGGCGCAGTTTAA
AAAGAAGCTCGCAGAAGTGCTGGTTCAACCGAGAGTAGAAAAAGCCCGGCTGCACGGCTTGCCGGATTGCTACAAGATAA
AGCTTCGCGCCTCGGGCTATCGGTTGATTTACCAGGTCAGAGACAACGTGGTGACGGTGTTTGTCGTGGCGATTGGTAAA
CGTGAAAAAGAGGCGGCTTACCACAGCGCTAATCACCGCCTGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9133.62 Da
• Isoelectric Point: 4.8537

>AT117248 WP_042714051.1 NZ_CP035129:c4136533-4136291 [Kosakonia cowanii]
MATLNVRLDDKLKEEAWKVLEKLDITPTEAVRLLFQYVAENGRMPVKTVTVSEDEAALLEVVRERLANPQKGIKVRLDDL

Nucleotide

• Length: 243 bp

>AT117248 NZ_CP035129:c4136533-4136291 [Kosakonia cowanii]
ATGGCAACGCTCAATGTTCGACTGGATGACAAGCTCAAAGAGGAGGCCTGGAAAGTGCTGGAGAAACTCGACATTACGCC
CACCGAAGCGGTGCGCCTGCTGTTTCAATACGTTGCAGAGAATGGCCGTATGCCGGTTAAAACCGTAACGGTGAGCGAAG
ACGAAGCGGCACTGCTGGAGGTGGTCAGAGAGCGCCTGGCGAACCCGCAAAAAGGGATCAAGGTCAGGCTGGATGATCTA
TGA