Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3660034..3660677 Replicon chromosome
Accession NZ_CP035129
Organism Kosakonia cowanii strain FBS 223

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag EQG67_RS17330 Protein ID WP_076769435.1
Coordinates 3660034..3660450 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag EQG67_RS17335 Protein ID WP_042715980.1
Coordinates 3660447..3660677 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQG67_RS17310 3656117..3657778 - 1662 WP_128484101.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -
EQG67_RS17320 3658677..3659129 + 453 WP_128484102.1 hypothetical protein -
EQG67_RS17325 3659325..3659939 - 615 WP_128483565.1 hypothetical protein -
EQG67_RS17330 3660034..3660450 - 417 WP_076769435.1 type II toxin-antitoxin system VapC family toxin Toxin
EQG67_RS17335 3660447..3660677 - 231 WP_042715980.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EQG67_RS17340 3661518..3661880 + 363 WP_128483566.1 hypothetical protein -
EQG67_RS17345 3661877..3662710 - 834 WP_128483567.1 DUF4225 domain-containing protein -
EQG67_RS17350 3662726..3663190 - 465 WP_128483568.1 type VI secretion system tube protein Hcp -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14986.30 Da        Isoelectric Point: 8.5258

>T117247 WP_076769435.1 NZ_CP035129:c3660450-3660034 [Kosakonia cowanii]
VNKTYMLDTNICSFIMREQPEAVLKRLEQTVLRNHRIVVSAITYAEMRFGAVGKKASPRHAKLVDAFCARLDAVLAWDRA
AVDATTEIKVALAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFARVPGLELEDWSR

Download         Length: 417 bp

>T117247 NZ_CP035129:c3660450-3660034 [Kosakonia cowanii]
GTGAACAAGACTTATATGCTCGACACAAATATTTGCTCATTCATCATGCGCGAGCAGCCTGAGGCAGTACTGAAACGCCT
GGAGCAGACCGTTCTGCGTAACCACCGCATCGTGGTATCGGCCATCACCTATGCCGAGATGCGCTTCGGTGCTGTCGGCA
AGAAAGCCTCACCGCGTCACGCAAAGCTTGTTGACGCATTCTGTGCTCGCCTTGATGCAGTTCTCGCCTGGGATCGTGCA
GCAGTGGATGCCACGACCGAAATTAAGGTCGCACTGGCCGCAGCCGGCACACCGATTGGTCCAAACGACACGGCGATTGC
AGGGCACGCCATTGCGGCCGGCGCTATTCTGGTGACCAACAATACCCGTGAGTTTGCTCGCGTTCCCGGACTCGAGCTTG
AAGACTGGAGCCGTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8767.85 Da        Isoelectric Point: 4.3654

>AT117247 WP_042715980.1 NZ_CP035129:c3660677-3660447 [Kosakonia cowanii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIIREGDSIILRPVRPTWGSFSQLEKADPDFMAEREDVVTDEGRFDL

Download         Length: 231 bp

>AT117247 NZ_CP035129:c3660677-3660447 [Kosakonia cowanii]
ATGAGAACCGTATCTATTTTCAAAAACGGCAATAACCGTGCCATACGCTTGCCCCGCGATCTGGATTTTGAAGGGGTGAG
TGAACTGGAGATCATTCGTGAAGGGGACAGCATCATCCTGCGTCCCGTGCGCCCCACTTGGGGCTCTTTCTCTCAACTTG
AGAAGGCCGATCCGGACTTTATGGCGGAGCGTGAGGACGTTGTCACCGATGAAGGACGATTTGATCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References