Detailed information of TA system TA117237

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 789306..789969
• Replicon: chromosome
• Accession: NZ_CP035129
• Organism: Kosakonia cowanii strain FBS 223

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: EQG67_RS03695
• Protein ID: WP_054803578.1
• Coordinates: 789553..789969 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A807LAC0
• Locus tag: EQG67_RS03690
• Protein ID: WP_023480982.1
• Coordinates: 789306..789572 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQG67_RS03670	784852..786285	-	1434	WP_128482144.1	6-phospho-beta-glucosidase	-
EQG67_RS03675	786402..787130	-	729	WP_023481032.1	MurR/RpiR family transcriptional regulator	-
EQG67_RS03680	787369..788028	+	660	WP_128482145.1	hemolysin III family protein	-
EQG67_RS03685	788079..789059	-	981	WP_128482146.1	tRNA-modifying protein YgfZ	-
EQG67_RS03690	789306..789572	+	267	WP_023480982.1	FAD assembly factor SdhE	Antitoxin
EQG67_RS03695	789553..789969	+	417	WP_054803578.1	protein YgfX	Toxin
EQG67_RS03700	789987..790508	-	522	WP_094422004.1	flavodoxin FldB	-
EQG67_RS03705	790608..791504	+	897	WP_023480693.1	site-specific tyrosine recombinase XerD	-
EQG67_RS03710	791529..792239	+	711	WP_042718296.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
EQG67_RS03715	792245..793978	+	1734	WP_128482147.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16454.36 Da
• Isoelectric Point: 10.7346

>T117237 WP_054803578.1 NZ_CP035129:789553-789969 [Kosakonia cowanii]
VVLWQSELRVSWRAQWLSLLLHGFVAALILLMPWPLSYTPVWLLLLSLVVFDSVRSQRRINACHGEIKLLMDSRLRWQGE
EWDIVGTPWMLRSGMMLRLRREEDGRRQHLWLASDSMDAQEWRDLRRMILQKPAQGLH

Nucleotide

• Length: 417 bp

>T117237 NZ_CP035129:789553-789969 [Kosakonia cowanii]
GTGGTCCTGTGGCAATCTGAGTTACGCGTCTCCTGGCGCGCACAGTGGCTCTCCTTACTGCTCCATGGATTCGTAGCCGC
ACTCATCTTGCTGATGCCATGGCCGCTGAGCTACACGCCGGTATGGCTGCTGCTGCTTTCGCTGGTGGTGTTTGACTCCG
TACGGAGCCAACGGCGCATTAACGCCTGTCATGGCGAGATTAAGTTGCTGATGGATTCCCGCCTGCGCTGGCAGGGCGAA
GAGTGGGATATTGTCGGTACGCCCTGGATGCTGCGTAGTGGGATGATGCTGCGTTTGCGTCGCGAGGAAGATGGGCGTCG
GCAGCATCTCTGGCTGGCATCAGACAGTATGGATGCGCAGGAGTGGCGCGATCTGCGCCGGATGATTTTACAAAAACCGG
CGCAGGGGCTGCACTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10556.01 Da
• Isoelectric Point: 5.6186

>AT117237 WP_023480982.1 NZ_CP035129:789306-789572 [Kosakonia cowanii]
MDITNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDDKRLFVRLLENDDPDLFNWLMNHGKPQDAELQRMVQLIQTRN
RDRGPVAI

Nucleotide

• Length: 267 bp

>AT117237 NZ_CP035129:789306-789572 [Kosakonia cowanii]
ATGGATATTACTAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGAATGCGCGAGCTCGATATTTCCATCATGCCTTT
TTTCGAACATGAGTACGATTCGCTAAGCGATGATGACAAGCGTCTCTTTGTCCGCCTGCTGGAAAATGACGATCCCGATT
TATTTAACTGGCTTATGAACCACGGCAAGCCACAGGATGCGGAGTTGCAAAGAATGGTGCAGTTAATCCAGACACGGAAT
CGGGATCGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A807LAC0