Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1860963..1861795 Replicon chromosome
Accession NZ_CP035123
Organism Escherichia coli strain EC25

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0Q2Y5N3
Locus tag EQK40_RS09015 Protein ID WP_001514886.1
Coordinates 1860963..1861337 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9IW59
Locus tag EQK40_RS09020 Protein ID WP_001360327.1
Coordinates 1861427..1861795 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQK40_RS08975 1856479..1856952 + 474 WP_001105385.1 DNA gyrase inhibitor SbmC -
EQK40_RS08980 1857151..1858209 + 1059 WP_032181141.1 FUSC family protein -
EQK40_RS08985 1858381..1858710 + 330 WP_000450409.1 DUF496 family protein -
EQK40_RS08990 1858811..1858993 - 183 WP_032181276.1 ethanolamine utilization protein -
EQK40_RS09000 1859447..1860475 - 1029 Protein_1738 IS110 family transposase -
EQK40_RS09005 1860634..1860747 - 114 WP_001161660.1 DUF957 domain-containing protein -
EQK40_RS09010 1860760..1860966 - 207 WP_000976829.1 hypothetical protein -
EQK40_RS09015 1860963..1861337 - 375 WP_001514886.1 TA system toxin CbtA family protein Toxin
EQK40_RS09020 1861427..1861795 - 369 WP_001360327.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EQK40_RS09025 1861958..1862179 - 222 WP_000692286.1 DUF987 domain-containing protein -
EQK40_RS09030 1862242..1862718 - 477 WP_001186774.1 RadC family protein -
EQK40_RS09035 1862734..1863207 - 474 WP_000855059.1 antirestriction protein -
EQK40_RS09045 1863549..1864367 - 819 WP_088540043.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13930.91 Da        Isoelectric Point: 7.2909

>T117217 WP_001514886.1 NZ_CP035123:c1861337-1860963 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T117217 NZ_CP035123:c1861337-1860963 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.34 Da        Isoelectric Point: 5.9598

>AT117217 WP_001360327.1 NZ_CP035123:c1861795-1861427 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT117217 NZ_CP035123:c1861795-1861427 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q2Y5N3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9IW59

References