Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 372287..372940 Replicon chromosome
Accession NZ_CP035109
Organism Acinetobacter pittii strain NQ-003

Toxin (Protein)


Gene name cptA Uniprot ID A0A013STE4
Locus tag EPY81_RS01795 Protein ID WP_005078321.1
Coordinates 372287..372676 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A009HHW9
Locus tag EPY81_RS01800 Protein ID WP_002117064.1
Coordinates 372683..372940 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPY81_RS01780 367378..369588 - 2211 WP_002116854.1 TRAP transporter large permease subunit -
EPY81_RS01785 369768..370343 - 576 WP_005078319.1 rhombosortase -
EPY81_RS01790 370428..371516 - 1089 WP_002116869.1 hypothetical protein -
EPY81_RS01795 372287..372676 - 390 WP_005078321.1 hypothetical protein Toxin
EPY81_RS01800 372683..372940 - 258 WP_002117064.1 succinate dehydrogenase assembly factor 2 Antitoxin
EPY81_RS01805 373129..374301 + 1173 WP_002116790.1 acyl-CoA dehydrogenase family protein -
EPY81_RS01810 374352..375842 - 1491 WP_002116796.1 NAD(P)/FAD-dependent oxidoreductase -
EPY81_RS01815 376023..376400 - 378 WP_002049717.1 50S ribosomal protein L17 -
EPY81_RS01820 376419..377426 - 1008 WP_002116730.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15476.61 Da        Isoelectric Point: 7.9230

>T117206 WP_005078321.1 NZ_CP035109:c372676-372287 [Acinetobacter pittii]
MIKELNFELKYSLVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSVAYFSKKEI
YRAEITKIIDYQLFVVIYLEETPTNIAIVWFDQLPIQQWKRLKVLEKLY

Download         Length: 390 bp

>T117206 NZ_CP035109:c372676-372287 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCTTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATCCTGCTTTATCAATTATTAACACCGATATGGTGGCTATGTGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCCCAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTTTCGAAAAAAGAAATT
TACCGCGCGGAAATTACTAAAATAATTGATTATCAGTTATTTGTAGTTATTTATCTTGAAGAAACTCCTACGAACATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAGCTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10295.73 Da        Isoelectric Point: 4.4809

>AT117206 WP_002117064.1 NZ_CP035109:c372940-372683 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Download         Length: 258 bp

>AT117206 NZ_CP035109:c372940-372683 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAACTATTATTTAAAAGCTGATCCAGCAGAAAAAGCATTATTTGCAGAGTTAGTCGATCAAGAAG
ATCCGGATTTATTAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTGCATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A013STE4

Antitoxin

Source ID Structure
AlphaFold DB A0A009HHW9

References