Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 976141..977699 Replicon chromosome
Accession NZ_CP035108
Organism Geovibrio thiophilus strain DSM 11263

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EP073_RS04540 Protein ID WP_128465988.1
Coordinates 976386..977699 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EP073_RS04535 Protein ID WP_128465987.1
Coordinates 976141..976386 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP073_RS04520 971554..973539 + 1986 WP_128465984.1 AAA family ATPase -
EP073_RS04525 973524..975473 + 1950 WP_128465985.1 ATP-dependent helicase -
EP073_RS04530 975524..975994 + 471 WP_128465986.1 hypothetical protein -
EP073_RS04535 976141..976386 + 246 WP_128465987.1 helix-turn-helix domain-containing protein Antitoxin
EP073_RS04540 976386..977699 + 1314 WP_128465988.1 type II toxin-antitoxin system HipA family toxin Toxin
EP073_RS13880 978602..978781 + 180 WP_206617524.1 SEC-C domain-containing protein -
EP073_RS04550 978957..979202 + 246 WP_128465989.1 helix-turn-helix domain-containing protein -
EP073_RS04555 979346..980464 + 1119 WP_164885273.1 HipA domain-containing protein -
EP073_RS04565 980822..982006 - 1185 WP_128465991.1 HipA domain-containing protein -
EP073_RS04570 982008..982220 - 213 WP_128465992.1 helix-turn-helix transcriptional regulator -
EP073_RS13820 982341..982514 - 174 WP_164885274.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 969383..1026682 57299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(154-404)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-69)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49063.51 Da        Isoelectric Point: 6.3200

>T117205 WP_128465988.1 NZ_CP035108:976386-977699 [Geovibrio thiophilus]
MGRRRKSSSLNLFMNGEAVGKLNRLSSGRLELLYDDEWMNSAFGRSISLSLPIVLKRHTGDVVENYFDNLLPDSMPIRNR
IQARFGIAKGDSFDLLAVIGKDCIGALQMLPEGVETDDFHRIVAEPLTDSSIAEILKNYRSMPLGMNDEDDFRISIAGAQ
EKTAFLSYKGQWCRPSGSTPTSHIFKLPIGRIEHNNIDLSDSVENEWLCHLLLKEFGLPVANAEIKEFADMKALVVERFD
RKWSEDGSWLFRLPQEDMCQAMGISPAIKYESSGGAGIESIMKLLLGSANSIEDRRIFMKAGFVFWLLGATDGHAKNFSI
FLEQGGRFRLTPLYDVMSVYPLVAKKELSLQNVKMAMSVSGKSKHYRWAEIQQRHWLATAKLCSFPEKEIKTIMDEVIGS
VDKAVSNVEALLPPFFPDSVSEPIFSMLNGQVKTFLV

Download         Length: 1314 bp

>T117205 NZ_CP035108:976386-977699 [Geovibrio thiophilus]
ATGGGACGCAGAAGAAAATCTTCAAGTCTCAATCTTTTTATGAACGGCGAAGCAGTCGGTAAGCTCAACCGTCTTTCATC
AGGAAGGCTGGAACTGCTTTACGATGATGAGTGGATGAATTCTGCGTTTGGTCGTTCAATCTCTCTTTCCCTCCCTATAG
TTTTGAAGCGTCATACGGGAGATGTTGTCGAAAACTATTTTGATAATCTTCTTCCGGACAGCATGCCTATACGCAACAGG
ATACAGGCGAGATTCGGTATTGCCAAAGGAGACAGCTTTGACCTGCTTGCAGTTATAGGCAAGGACTGCATAGGCGCTTT
GCAGATGCTGCCGGAAGGTGTTGAAACAGATGATTTTCACCGGATAGTTGCAGAGCCTTTGACAGATAGTAGTATTGCTG
AAATTCTAAAAAACTACAGATCCATGCCGCTCGGTATGAACGACGAAGATGATTTCAGAATTTCAATTGCCGGAGCGCAG
GAAAAAACAGCTTTTTTATCATATAAAGGACAATGGTGCAGACCGTCAGGCTCCACTCCGACAAGCCATATTTTCAAGCT
CCCTATAGGCAGAATAGAGCACAATAATATTGATTTATCGGACAGTGTTGAAAATGAATGGCTGTGCCATTTATTGCTCA
AAGAATTCGGTTTGCCTGTTGCAAATGCTGAAATCAAAGAATTTGCAGATATGAAGGCTCTCGTTGTCGAACGCTTCGAC
AGAAAATGGTCTGAGGACGGTTCATGGTTGTTCCGTCTTCCTCAGGAGGATATGTGTCAGGCGATGGGCATATCCCCTGC
AATAAAATACGAGAGTAGCGGTGGCGCAGGGATTGAAAGCATAATGAAGCTTTTACTCGGCTCTGCAAACAGTATTGAAG
ATCGCAGGATATTCATGAAGGCTGGGTTTGTATTCTGGCTACTGGGAGCAACAGACGGTCATGCCAAGAATTTCAGCATA
TTCCTTGAACAGGGCGGACGTTTCAGGCTTACGCCTCTTTATGATGTGATGTCGGTTTATCCGTTAGTAGCCAAGAAAGA
GCTTTCATTGCAGAATGTCAAGATGGCTATGTCCGTGTCCGGGAAATCAAAACACTACAGATGGGCAGAAATACAGCAAA
GGCACTGGCTGGCAACTGCCAAGCTGTGCAGCTTTCCTGAAAAAGAAATAAAAACGATAATGGATGAGGTTATCGGCTCA
GTTGATAAGGCTGTCAGCAATGTTGAAGCTCTGTTGCCGCCTTTTTTCCCTGATTCGGTATCAGAGCCTATATTCAGTAT
GCTTAATGGACAAGTGAAGACATTTTTAGTGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9035.44 Da        Isoelectric Point: 10.6883

>AT117205 WP_128465987.1 NZ_CP035108:976141-976386 [Geovibrio thiophilus]
MQNQIISSAKILGKAIKAFRERKGLTQKELADLVGVKQSTVSNIETASGDLRLSTLFRLISALEADMTFNERKKKNNPDA
W

Download         Length: 246 bp

>AT117205 NZ_CP035108:976141-976386 [Geovibrio thiophilus]
ATGCAAAATCAGATTATATCATCTGCAAAGATTCTTGGGAAGGCGATTAAAGCATTTCGTGAGAGAAAGGGGCTTACGCA
AAAGGAATTGGCGGATCTTGTCGGTGTCAAACAGTCAACCGTATCCAACATTGAAACCGCAAGCGGAGATTTGCGATTAA
GCACTTTGTTTCGTCTTATATCTGCACTTGAAGCTGATATGACTTTCAACGAGCGGAAAAAGAAAAATAATCCGGATGCT
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References