Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 468072..468624 Replicon chromosome
Accession NZ_CP035108
Organism Geovibrio thiophilus strain DSM 11263

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EP073_RS02250 Protein ID WP_128465545.1
Coordinates 468072..468344 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EP073_RS02255 Protein ID WP_128465546.1
Coordinates 468334..468624 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP073_RS02220 463334..464200 - 867 WP_128465539.1 flagellar basal body P-ring formation protein FlgA -
EP073_RS02225 464216..465004 - 789 WP_128465540.1 flagellar basal-body rod protein FlgG -
EP073_RS02230 465017..465781 - 765 WP_128465541.1 flagellar basal-body rod protein FlgF -
EP073_RS02235 465785..466642 - 858 WP_128465542.1 hypothetical protein -
EP073_RS02240 466706..467527 + 822 WP_128465543.1 nitroreductase family protein -
EP073_RS02245 467551..467922 - 372 WP_128465544.1 PilZ domain-containing protein -
EP073_RS02250 468072..468344 - 273 WP_128465545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EP073_RS02255 468334..468624 - 291 WP_128465546.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EP073_RS02260 468765..469373 + 609 WP_128465547.1 hypothetical protein -
EP073_RS02265 469486..469800 - 315 WP_128465548.1 helix-turn-helix domain-containing protein -
EP073_RS02270 470257..470646 + 390 WP_128465549.1 hypothetical protein -
EP073_RS02275 470675..470959 + 285 WP_128465550.1 hypothetical protein -
EP073_RS02280 471034..471693 + 660 WP_128465551.1 HAD hydrolase-like protein -
EP073_RS02285 471686..472309 + 624 WP_128465552.1 amidophosphoribosyltransferase -
EP073_RS02290 472365..473261 + 897 WP_206617488.1 DNA-processing protein DprA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-82)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10579.24 Da        Isoelectric Point: 5.1358

>T117203 WP_128465545.1 NZ_CP035108:c468344-468072 [Geovibrio thiophilus]
VRIEWKDKAVEDLLTILAYIADDSTEASQALKELIDEKVNGLLLYPQMYKEGRVKNTRELIIHPSYILIYAEKDNIIDIL
RILHSRQQWP

Download         Length: 273 bp

>T117203 NZ_CP035108:c468344-468072 [Geovibrio thiophilus]
GTGCGTATTGAGTGGAAAGACAAGGCTGTTGAGGATTTGCTGACCATACTTGCATATATTGCTGATGATAGTACAGAAGC
CTCTCAGGCACTGAAAGAGTTGATAGATGAAAAAGTAAACGGATTGCTCCTTTATCCTCAAATGTATAAAGAAGGACGGG
TCAAAAATACACGTGAACTAATCATTCATCCCAGCTACATATTAATTTATGCAGAAAAAGATAATATAATAGATATTCTG
CGCATTCTTCATAGCAGGCAGCAATGGCCTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10823.54 Da        Isoelectric Point: 6.7204

>AT117203 WP_128465546.1 NZ_CP035108:c468624-468334 [Geovibrio thiophilus]
MPKTSMLHVRIEEDLKAEAAETLANFGLTVSDAVRILLTRIVKEGALPIGLTSDPEAYDLWFHAKVREALESTKSEEHKE
VMNKAQILINRKKCAY

Download         Length: 291 bp

>AT117203 NZ_CP035108:c468624-468334 [Geovibrio thiophilus]
ATGCCTAAAACATCCATGCTGCATGTCAGAATTGAAGAAGATTTAAAAGCCGAGGCTGCTGAAACGCTCGCCAATTTCGG
GCTAACTGTTTCAGATGCCGTAAGAATCCTCTTGACACGCATTGTTAAAGAAGGAGCACTGCCGATCGGATTGACAAGTG
ATCCGGAAGCGTATGATCTCTGGTTTCATGCAAAAGTGAGGGAAGCTCTTGAAAGTACAAAGTCAGAAGAGCATAAAGAA
GTAATGAATAAAGCCCAGATCTTAATAAACCGGAAAAAATGTGCGTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References