Detailed information of TA system TA117202

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 568920..569439
• Replicon: chromosome
• Accession: NZ_CP035106
• Organism: Helicobacter pylori strain Hpbs3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EM806_RS02835
• Protein ID: WP_128479698.1
• Coordinates: 569218..569439 (+)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EM806_RS02830
• Protein ID: WP_128479696.1
• Coordinates: 568920..569231 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EM806_RS02790	563933..564169	+	237	WP_128479688.1	HypC/HybG/HupF family hydrogenase formation chaperone	-
EM806_RS02795	564197..565309	+	1113	WP_128479689.1	hydrogenase formation protein HypD	-
EM806_RS02800	565260..565877	-	618	WP_128479691.1	hypothetical protein	-
EM806_RS02820	566282..568519	+	2238	WP_128479693.1	Hop family adhesin BabA	-
EM806_RS02830	568920..569231	+	312	WP_128479696.1	hypothetical protein	Antitoxin
EM806_RS02835	569218..569439	+	222	WP_128479698.1	YafQ family addiction module toxin	Toxin
EM806_RS02840	569597..570121	-	525	WP_128479700.1	acyl-CoA thioesterase	-
EM806_RS02845	570261..571103	+	843	WP_128479701.1	SDR family oxidoreductase	-
EM806_RS02850	571096..572076	+	981	WP_000921438.1	iron ABC transporter permease	-
EM806_RS02855	572076..572843	+	768	WP_033587234.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-72)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8627.38 Da
• Isoelectric Point: 9.9382

>T117202 WP_128479698.1 NZ_CP035106:569218-569439 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKILYKVVENLAKEQPLDPKYKDHPLKGALKDFRECHLKPDLLLVYQIKK

Nucleotide

• Length: 222 bp

>T117202 NZ_CP035106:569218-569439 [Helicobacter pylori]
ATGCTGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGATTTGATTTAAAGATTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGATCCCAAATACAAAGACCACCCGCTCAAAGGCGCTTTAA
AAGATTTTAGGGAATGCCACTTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAATAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12288.14 Da
• Isoelectric Point: 10.2819

>AT117202 WP_128479696.1 NZ_CP035106:568920-569231 [Helicobacter pylori]
MPNSPTKKDYTRYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDAKNH
LCFKSVEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT117202 NZ_CP035106:568920-569231 [Helicobacter pylori]
ATGCCTAACTCTCCCACCAAAAAAGATTACACACGATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCACTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACGCCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA