117189

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 820590..821067 Replicon chromosome
Accession NZ_CP035101
Organism Staphylococcus aureus strain ATCC 12600

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag EQG65_RS04000 Protein ID WP_000052078.1
Coordinates 820590..820778 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EQG65_RS04005 Protein ID WP_001059690.1
Coordinates 820807..821067 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQG65_RS03970 816631..817101 + 471 WP_000824472.1 hypothetical protein -
EQG65_RS03975 817442..818128 + 687 WP_001548082.1 thermonuclease family protein -
EQG65_RS03980 818485..818685 + 201 WP_001059082.1 cold-shock protein -
EQG65_RS03985 819181..819399 - 219 WP_000005886.1 hypothetical protein -
EQG65_RS03990 819461..819745 - 285 WP_001004395.1 hypothetical protein -
EQG65_RS03995 819833..820402 - 570 WP_001106654.1 hypothetical protein -
EQG65_RS04000 820590..820778 - 189 WP_000052078.1 hypothetical protein Toxin
EQG65_RS04005 820807..821067 - 261 WP_001059690.1 hypothetical protein Antitoxin
EQG65_RS04010 821408..821611 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EQG65_RS04015 821608..821844 - 237 WP_000368687.1 hypothetical protein -
EQG65_RS04020 822069..822650 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
EQG65_RS04025 822723..823340 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
EQG65_RS04030 823495..823989 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
EQG65_RS04035 824388..824810 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
EQG65_RS04040 824958..825674 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T117189 WP_000052078.1 NZ_CP035101:c820778-820590 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T117189 NZ_CP035101:c820778-820590 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT117189 WP_001059690.1 NZ_CP035101:c821067-820807 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT117189 NZ_CP035101:c821067-820807 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References