Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 967189..967718 Replicon chromosome
Accession NZ_CP035091
Organism Paracoccus denitrificans strain ATCC 19367

Toxin (Protein)


Gene name parE Uniprot ID A1B8Q3
Locus tag EO213_RS19500 Protein ID WP_011750065.1
Coordinates 967431..967718 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0V0Q4K1
Locus tag EO213_RS19495 Protein ID WP_010396097.1
Coordinates 967189..967434 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EO213_RS19465 962444..962896 - 453 WP_011750059.1 CoA-binding protein -
EO213_RS19470 963080..963493 - 414 WP_011750060.1 YHS domain-containing protein -
EO213_RS19475 963594..964391 - 798 WP_011750061.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
EO213_RS19485 964873..965730 + 858 WP_011750063.1 hypothetical protein -
EO213_RS19490 965723..967084 + 1362 WP_011750064.1 plasmid recombination protein -
EO213_RS19495 967189..967434 + 246 WP_010396097.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
EO213_RS19500 967431..967718 + 288 WP_011750065.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EO213_RS19505 967777..968310 + 534 WP_041530416.1 hypothetical protein -
EO213_RS19510 968535..969707 - 1173 WP_011750067.1 ATP-binding protein -
EO213_RS19515 970035..970244 - 210 WP_011748680.1 hypothetical protein -
EO213_RS19520 970386..970664 - 279 WP_041530417.1 hypothetical protein -
EO213_RS19525 970661..971170 - 510 WP_011750069.1 hypothetical protein -
EO213_RS19530 971167..971349 - 183 WP_028717528.1 hypothetical protein -
EO213_RS19535 971346..971669 - 324 WP_011750070.1 zinc ribbon domain-containing protein -
EO213_RS19540 971779..972024 + 246 WP_011750071.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 964620..983343 18723


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(1-76)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10768.19 Da        Isoelectric Point: 6.0765

>T117186 WP_011750065.1 NZ_CP035091:967431-967718 [Paracoccus denitrificans]
VKALAFTVAATVDLEDIWDYTEGEWGLAQARRYAEELRDTCHALASGERRGRKVDVRPGYLKCLSGSHIIFFRDLGDTLE
IVRILHGAQDVERHL

Download         Length: 288 bp

>T117186 NZ_CP035091:967431-967718 [Paracoccus denitrificans]
GTGAAGGCATTGGCCTTCACCGTCGCGGCAACGGTCGATCTGGAGGATATCTGGGATTATACGGAAGGCGAATGGGGTCT
GGCGCAAGCCCGGCGGTATGCGGAGGAGCTGCGCGACACCTGCCACGCGCTGGCTTCGGGCGAAAGGCGCGGCAGGAAAG
TTGACGTTCGGCCCGGCTATCTGAAGTGCCTGAGCGGGTCGCATATCATCTTTTTCCGGGATCTGGGCGATACGCTGGAA
ATCGTCCGCATCCTGCACGGTGCACAGGACGTCGAGCGGCATTTGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8708.75 Da        Isoelectric Point: 6.4631

>AT117186 WP_010396097.1 NZ_CP035091:967189-967434 [Paracoccus denitrificans]
MSRNTSVSLGDHFVSFIDAQVKGGRYGSASDVVRAGLRLLEEHEAKVKALQDALIAGEDSGRAEGFDLDQFIARKMAGRN
A

Download         Length: 246 bp

>AT117186 NZ_CP035091:967189-967434 [Paracoccus denitrificans]
ATGTCCCGCAACACTTCGGTTTCGCTCGGCGATCACTTCGTCAGCTTCATCGACGCGCAGGTGAAGGGCGGCCGCTATGG
CTCGGCCAGCGACGTGGTGCGGGCGGGGCTGCGGCTTCTGGAGGAGCACGAGGCCAAGGTAAAGGCCCTCCAGGACGCCC
TGATCGCGGGAGAGGACTCCGGCCGGGCGGAGGGCTTCGACCTCGATCAGTTCATTGCCCGCAAGATGGCCGGTCGCAAT
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A1B8Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A0V0Q4K1

References