Detailed information of TA system TA117185

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 742407..742968
• Replicon: chromosome
• Accession: NZ_CP035091
• Organism: Paracoccus denitrificans strain ATCC 19367

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A1B816
• Locus tag: EO213_RS18195
• Protein ID: WP_011749829.1
• Coordinates: 742693..742968 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A1B815
• Locus tag: EO213_RS18190
• Protein ID: WP_011749828.1
• Coordinates: 742407..742700 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EO213_RS18175	738141..739232	-	1092	WP_011749823.1	transglutaminase domain-containing protein	-
EO213_RS18180	739419..740141	-	723	WP_104494217.1	outer membrane beta-barrel protein	-
EO213_RS18185	740156..741604	-	1449	WP_011749825.1	amidohydrolase family protein	-
EO213_RS18190	742407..742700	+	294	WP_011749828.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EO213_RS18195	742693..742968	+	276	WP_011749829.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
EO213_RS18200	743176..744712	-	1537	Protein_751	IS66 family transposase	-
EO213_RS18205	744771..745118	-	348	WP_011749831.1	IS66 family insertion sequence element accessory protein TnpB	-
EO213_RS18215	745184..747310	+	2127	WP_164901620.1	tape measure protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	744771..745064	293

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-53)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10286.90 Da
• Isoelectric Point: 5.8449

>T117185 WP_011749829.1 NZ_CP035091:742693-742968 [Paracoccus denitrificans]
VPEVEWRQAAREDLRSIFEYIADDNPTAALALLDEIEAKVGKLPDRLRAYRPGRVTGTREMVVRPNYLVVYAEVGGALVI
LRVLHAAQMWP

Nucleotide

• Length: 276 bp

>T117185 NZ_CP035091:742693-742968 [Paracoccus denitrificans]
GTGCCTGAGGTGGAATGGCGGCAAGCCGCGCGCGAGGACCTGCGTTCGATCTTCGAGTACATCGCCGATGACAATCCGAC
AGCGGCACTTGCGCTGCTGGATGAGATCGAGGCAAAGGTTGGCAAGTTGCCTGATCGGCTTAGAGCGTATCGGCCGGGCA
GGGTGACAGGGACACGCGAAATGGTCGTCCGGCCTAACTATCTTGTGGTCTATGCTGAGGTCGGGGGAGCGCTGGTGATC
CTGCGGGTCTTGCATGCGGCGCAGATGTGGCCGTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10719.32 Da
• Isoelectric Point: 5.1457

>AT117185 WP_011749828.1 NZ_CP035091:742407-742700 [Paracoccus denitrificans]
MPAQTSMLHVRVDDQLKAQAAEALAGVGLTLSDAVRILLTRVAREGGLPAGLTADPDVYDAWFRAKVREALEDDQPTIPH
VDIMAEMRELIERKRRA

Nucleotide

• Length: 294 bp

>AT117185 NZ_CP035091:742407-742700 [Paracoccus denitrificans]
ATGCCCGCACAAACTTCGATGCTGCACGTCCGCGTGGACGACCAACTCAAGGCCCAAGCTGCTGAGGCGCTGGCTGGCGT
CGGCCTGACCCTGTCGGATGCGGTTCGCATCCTGTTGACCCGCGTTGCGCGGGAGGGCGGGTTGCCGGCCGGTTTGACAG
CCGACCCGGACGTCTATGACGCGTGGTTCCGCGCCAAGGTTCGCGAAGCGCTTGAGGATGACCAGCCGACCATCCCGCAT
GTCGATATCATGGCGGAAATGCGCGAACTGATCGAGCGGAAGCGCCGTGCCTGA

Structures

Toxin

• AlphaFold DB: A1B816

Antitoxin

• AlphaFold DB: A1B815