Detailed information of TA system TA117183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2047405..2048066
• Replicon: chromosome
• Accession: NZ_CP035090
• Organism: Paracoccus denitrificans strain ATCC 19367

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EO213_RS10350
• Protein ID: WP_041529753.1
• Coordinates: 2047677..2048066 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A5P8JJZ9
• Locus tag: EO213_RS10345
• Protein ID: WP_011746827.1
• Coordinates: 2047405..2047668 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EO213_RS10325	2043243..2044409	+	1167	WP_011746823.1	alpha/beta hydrolase	-
EO213_RS10330	2044406..2045179	+	774	WP_011746824.1	SDR family oxidoreductase	-
EO213_RS10335	2045315..2046553	+	1239	WP_011746825.1	MFS transporter	-
EO213_RS10340	2046748..2047083	-	336	WP_128492979.1	hypothetical protein	-
EO213_RS10345	2047405..2047668	+	264	WP_011746827.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
EO213_RS10350	2047677..2048066	+	390	WP_041529753.1	type II toxin-antitoxin system VapC family toxin	Toxin
EO213_RS10360	2048894..2049232	+	339	WP_011746829.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EO213_RS10365	2049229..2049507	+	279	WP_041529754.1	helix-turn-helix domain-containing protein	-
EO213_RS10370	2049617..2050000	+	384	WP_011746831.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-120)

Antitoxin

• SpoVT-AbrB domain (16-53)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 13626.62 Da
• Isoelectric Point: 5.1700

>T117183 WP_041529753.1 NZ_CP035090:2047677-2048066 [Paracoccus denitrificans]
MLDTNIVSDLLRHPDGSAAKRIAEVGPDAICVSIITAAELRYGCARKGSAKLLAHVEAILENVQVLALDVPADAEYGGIR
AELEAAGKPIGPNDLLIAAHAYAAGAILVTDNTGEFSRVRGLRVENWIR

Nucleotide

• Length: 390 bp

>T117183 NZ_CP035090:2047677-2048066 [Paracoccus denitrificans]
ATGCTCGACACCAATATCGTCTCCGATCTGCTGCGACATCCTGACGGCAGCGCGGCAAAGCGCATTGCCGAGGTCGGCCC
GGATGCGATCTGCGTGAGCATCATCACAGCCGCAGAGCTGCGATATGGGTGCGCCAGGAAAGGGTCTGCGAAACTCCTGG
CGCATGTCGAGGCGATACTGGAAAATGTGCAGGTTCTGGCGCTCGATGTGCCTGCTGACGCGGAGTATGGCGGCATTCGT
GCCGAGCTTGAGGCCGCTGGCAAGCCCATTGGTCCAAACGATCTGTTGATCGCAGCTCATGCCTACGCCGCAGGCGCAAT
CCTCGTGACTGACAACACGGGCGAGTTTTCCCGCGTTCGCGGCCTGCGGGTTGAAAACTGGATCAGGTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9842.23 Da
• Isoelectric Point: 4.8232

>AT117183 WP_011746827.1 NZ_CP035090:2047405-2047668 [Paracoccus denitrificans]
MPHPQPSSGPREAKLFRNNKSQAVRIPADFEMPGDRVNIYRDGNRLIIEPLRRKNLLEVLAGLDPLGPEDQFPDVDETLL
PAKEIDL

Nucleotide

• Length: 264 bp

>AT117183 NZ_CP035090:2047405-2047668 [Paracoccus denitrificans]
ATGCCGCATCCGCAGCCATCTTCAGGGCCTCGTGAAGCCAAGCTCTTCCGCAACAACAAGAGCCAGGCCGTCCGCATCCC
GGCTGACTTCGAGATGCCGGGGGATCGGGTGAACATCTATCGTGACGGGAACCGGCTTATCATCGAGCCGCTGCGCCGCA
AGAACCTGCTTGAAGTGCTGGCCGGACTAGACCCGCTTGGGCCAGAGGATCAGTTTCCTGATGTGGACGAGACGCTTCTC
CCGGCCAAGGAAATCGACCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A5P8JJZ9