Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 818016..818686 Replicon chromosome
Accession NZ_CP035090
Organism Paracoccus denitrificans strain ATCC 19367

Toxin (Protein)


Gene name vapC Uniprot ID A0A5P8JDY4
Locus tag EO213_RS04040 Protein ID WP_011748362.1
Coordinates 818252..818686 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A1B3S2
Locus tag EO213_RS04035 Protein ID WP_011748361.1
Coordinates 818016..818255 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EO213_RS04005 813202..814563 - 1362 WP_049792366.1 site-specific DNA-methyltransferase -
EO213_RS04010 814692..815087 - 396 WP_011748356.1 HNH endonuclease -
EO213_RS04015 815175..815552 - 378 WP_011748357.1 hypothetical protein -
EO213_RS04020 815545..815745 - 201 WP_036744895.1 hypothetical protein -
EO213_RS04025 816090..817695 - 1606 Protein_778 hypothetical protein -
EO213_RS04030 817692..817892 - 201 WP_011748360.1 hypothetical protein -
EO213_RS04035 818016..818255 + 240 WP_011748361.1 Arc family DNA-binding protein Antitoxin
EO213_RS04040 818252..818686 + 435 WP_011748362.1 type II toxin-antitoxin system VapC family toxin Toxin
EO213_RS04045 818674..819390 - 717 WP_011748363.1 sigma-70 family RNA polymerase sigma factor -
EO213_RS04055 819815..821977 - 2163 WP_011748365.1 hypothetical protein -
EO213_RS04065 822311..822766 + 456 WP_011748367.1 DUF2924 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 799131..824091 24960


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin

Arc-like DNA binding domain

(3-42)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15536.75 Da        Isoelectric Point: 4.5849

>T117181 WP_011748362.1 NZ_CP035090:818252-818686 [Paracoccus denitrificans]
MIILDTNVVSETMKPAPEPRVIDWLNRQELTTLHLTTISLAELRFGIACLDAGRRRDDLDARLEQMLAEVFPARILSFDE
AAASAFGVLMATARRQGQAVSFADGAIAAIAAAQGYPVASRDTAPFAAMGVEVVDPWHEAAQGR

Download         Length: 435 bp

>T117181 NZ_CP035090:818252-818686 [Paracoccus denitrificans]
ATGATCATCCTCGACACCAATGTCGTCTCGGAGACGATGAAGCCGGCGCCAGAGCCGCGGGTGATCGACTGGCTCAACCG
GCAAGAGCTGACCACCCTGCACCTGACCACCATCAGCCTGGCCGAGTTGCGGTTCGGCATTGCATGCCTGGACGCTGGGC
GTCGTCGGGACGATCTTGACGCGCGGCTCGAGCAGATGCTGGCCGAGGTATTTCCGGCACGTATCCTGTCGTTCGACGAG
GCCGCTGCCAGTGCCTTCGGAGTATTGATGGCAACGGCGCGCCGGCAGGGACAGGCCGTGAGTTTTGCCGATGGCGCGAT
TGCTGCCATTGCCGCGGCACAGGGCTATCCCGTCGCCAGCCGCGACACCGCGCCCTTCGCCGCCATGGGCGTAGAGGTGG
TGGATCCGTGGCACGAGGCGGCTCAAGGCCGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8685.85 Da        Isoelectric Point: 7.2058

>AT117181 WP_011748361.1 NZ_CP035090:818016-818255 [Paracoccus denitrificans]
MAQIVVRQIPEEVHRALKAQAAAHGRSAEAELREIIARAVLPQSRPRAGDLMRSIWSGAETDDLSVERDRTPAKPAGFE

Download         Length: 240 bp

>AT117181 NZ_CP035090:818016-818255 [Paracoccus denitrificans]
ATGGCCCAGATCGTCGTACGCCAGATCCCGGAAGAGGTGCATCGCGCGCTGAAGGCGCAGGCGGCTGCCCATGGTCGCAG
CGCCGAGGCCGAGTTGCGCGAGATCATTGCCCGCGCGGTGCTGCCGCAGTCGCGCCCGCGCGCGGGTGATCTGATGCGCA
GTATCTGGTCCGGCGCCGAGACGGACGACCTTTCGGTCGAACGCGACCGGACGCCCGCGAAGCCGGCCGGTTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P8JDY4

Antitoxin

Source ID Structure
AlphaFold DB A1B3S2

References