Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1549646..1550273 Replicon chromosome
Accession NZ_CP035088
Organism Pseudomonas viciae strain 11K1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EPZ47_RS07130 Protein ID WP_135844147.1
Coordinates 1550058..1550273 (-) Length 72 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EPZ47_RS07125 Protein ID WP_135844146.1
Coordinates 1549646..1550056 (-) Length 137 a.a.

Genomic Context

EPZ47_RS07095EPZ47_RS07100EPZ47_RS07110EPZ47_RS07115EPZ47_RS30195EPZ47_RS07140EPZ47_RS07120EPZ47_RS07125EPZ47_RS07130EPZ47_RS07135EPZ47_RS07145EPZ47_RS07155EPZ47_RS07160EPZ47_RS07165
Location: 1545043..1545459 (417 bp)
Type: Others
Protein ID: WP_135844141.1
Location: 1545648..1546997 (1350 bp)
Type: Others
Protein ID: WP_135844142.1
Location: 1547279..1547782 (504 bp)
Type: Others
Protein ID: WP_135844143.1
Location: 1547859..1548767 (909 bp)
Type: Others
Protein ID: WP_135844144.1
Location: 1549394..1549540 (147 bp)
Type: Others
Protein ID: WP_178084240.1
Location: 1551336..1551815 (480 bp)
Type: Others
Protein ID: WP_135844149.1
Location: 1548816..1549220 (405 bp)
Type: Others
Protein ID: WP_135844145.1
Location: 1549646..1550056 (411 bp)
Type: Antitoxin
Protein ID: WP_135844146.1
Location: 1550058..1550273 (216 bp)
Type: Toxin
Protein ID: WP_135844147.1
Location: 1550561..1551190 (630 bp)
Type: Others
Protein ID: WP_135844148.1
Location: 1551839..1552393 (555 bp)
Type: Others
Protein ID: WP_135847960.1
Location: 1552778..1553662 (885 bp)
Type: Others
Protein ID: WP_135844150.1
Location: 1553972..1554664 (693 bp)
Type: Others
Protein ID: WP_135844151.1
Location: 1554700..1554918 (219 bp)
Type: Others
Protein ID: WP_135844152.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EPZ47_RS070951545043..1545459+417WP_135844141.1fosfomycin resistance glutathione transferase-
EPZ47_RS071001545648..1546997+1350WP_135844142.1sensor domain-containing diguanylate cyclase-
EPZ47_RS071101547279..1547782+504WP_135844143.1DUF4142 domain-containing protein-
EPZ47_RS071151547859..1548767+909WP_135844144.1SDR family oxidoreductase-
EPZ47_RS071201548816..1549220-405WP_135844145.1low affinity iron permease family protein-
EPZ47_RS301951549394..1549540+147WP_178084240.1hypothetical protein-
EPZ47_RS071251549646..1550056-411WP_135844146.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
EPZ47_RS071301550058..1550273-216WP_135844147.1type II toxin-antitoxin system HicA family toxinToxin
EPZ47_RS071351550561..1551190-630WP_135844148.1LysE family translocator-
EPZ47_RS071401551336..1551815+480WP_135844149.1Lrp/AsnC family transcriptional regulator-
EPZ47_RS071451551839..1552393-555WP_135847960.1hypothetical protein-
EPZ47_RS071551552778..1553662-885WP_135844150.1alpha/beta hydrolase-
EPZ47_RS071601553972..1554664-693WP_135844151.1pseudouridine synthase-
EPZ47_RS071651554700..1554918-219WP_135844152.1cysteine-rich CWC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 7755.97 Da        Isoelectric Point: 10.2823

>T117179 WP_135844147.1 NZ_CP035088:c1550273-1550058 [Pseudomonas viciae]
VNSRFLISQIIADGGYLVRVRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALLQTASCATSAEDD

Download         Length: 216 bp

>T117179 NZ_CP035088:c1550273-1550058 [Pseudomonas viciae]
GTGAATAGCCGATTTCTGATAAGCCAAATTATTGCGGACGGTGGGTATCTGGTGCGGGTTCGGGGCAGTCACCATCACTT
CAAGCATCCGACCAAGCCGGGGCTGGTGACGGTACCCCATCCAAAGAAGGACCTGCTCAAAAAAACGGCCATCAGTATTT
TGCAACAGGCGCTGCTTCAGACGGCCAGTTGCGCTACGTCTGCGGAGGACGATTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14764.82 Da        Isoelectric Point: 4.7269

>AT117179 WP_135844146.1 NZ_CP035088:c1550056-1549646 [Pseudomonas viciae]
MLYPIAISMGDDKHAWGVEVPDIPGCFSAGDDLDEAMAMAREAIEGHFEILAEDGSPIPSANTVTLHAANPKYAGCTWAL
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQGR

Download         Length: 411 bp

>AT117179 NZ_CP035088:c1550056-1549646 [Pseudomonas viciae]
ATGCTTTACCCGATTGCGATTTCCATGGGCGATGACAAGCACGCCTGGGGTGTTGAGGTGCCGGATATTCCCGGCTGTTT
TTCCGCTGGCGACGACCTGGACGAGGCCATGGCGATGGCACGTGAGGCCATTGAGGGGCACTTCGAGATTCTGGCTGAAG
ACGGTTCGCCGATTCCGTCGGCCAATACCGTCACCTTGCATGCAGCCAATCCAAAATATGCCGGCTGCACTTGGGCGCTG
GTGGACATTGATGTGACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACTTTGCCTGGCTACCTGCTCAATCGTAT
TGATGAATATGTGTTGCACCATCCTGAGGAAAAAAGCCGCTCAGGTTTTCTGGCTTCGGCGGCGCTGAAAGTGCTGCAGC
AGGGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References