Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1549646..1550273 Replicon chromosome
Accession NZ_CP035088
Organism Pseudomonas viciae strain 11K1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EPZ47_RS07130 Protein ID WP_135844147.1
Coordinates 1550058..1550273 (-) Length 72 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EPZ47_RS07125 Protein ID WP_135844146.1
Coordinates 1549646..1550056 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPZ47_RS07095 1545043..1545459 + 417 WP_135844141.1 fosfomycin resistance glutathione transferase -
EPZ47_RS07100 1545648..1546997 + 1350 WP_135844142.1 sensor domain-containing diguanylate cyclase -
EPZ47_RS07110 1547279..1547782 + 504 WP_135844143.1 DUF4142 domain-containing protein -
EPZ47_RS07115 1547859..1548767 + 909 WP_135844144.1 SDR family oxidoreductase -
EPZ47_RS07120 1548816..1549220 - 405 WP_135844145.1 low affinity iron permease family protein -
EPZ47_RS30195 1549394..1549540 + 147 WP_178084240.1 hypothetical protein -
EPZ47_RS07125 1549646..1550056 - 411 WP_135844146.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EPZ47_RS07130 1550058..1550273 - 216 WP_135844147.1 type II toxin-antitoxin system HicA family toxin Toxin
EPZ47_RS07135 1550561..1551190 - 630 WP_135844148.1 LysE family translocator -
EPZ47_RS07140 1551336..1551815 + 480 WP_135844149.1 Lrp/AsnC family transcriptional regulator -
EPZ47_RS07145 1551839..1552393 - 555 WP_135847960.1 hypothetical protein -
EPZ47_RS07155 1552778..1553662 - 885 WP_135844150.1 alpha/beta hydrolase -
EPZ47_RS07160 1553972..1554664 - 693 WP_135844151.1 pseudouridine synthase -
EPZ47_RS07165 1554700..1554918 - 219 WP_135844152.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 7755.97 Da        Isoelectric Point: 10.2823

>T117179 WP_135844147.1 NZ_CP035088:c1550273-1550058 [Pseudomonas viciae]
VNSRFLISQIIADGGYLVRVRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALLQTASCATSAEDD

Download         Length: 216 bp

>T117179 NZ_CP035088:c1550273-1550058 [Pseudomonas viciae]
GTGAATAGCCGATTTCTGATAAGCCAAATTATTGCGGACGGTGGGTATCTGGTGCGGGTTCGGGGCAGTCACCATCACTT
CAAGCATCCGACCAAGCCGGGGCTGGTGACGGTACCCCATCCAAAGAAGGACCTGCTCAAAAAAACGGCCATCAGTATTT
TGCAACAGGCGCTGCTTCAGACGGCCAGTTGCGCTACGTCTGCGGAGGACGATTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14764.82 Da        Isoelectric Point: 4.7269

>AT117179 WP_135844146.1 NZ_CP035088:c1550056-1549646 [Pseudomonas viciae]
MLYPIAISMGDDKHAWGVEVPDIPGCFSAGDDLDEAMAMAREAIEGHFEILAEDGSPIPSANTVTLHAANPKYAGCTWAL
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQGR

Download         Length: 411 bp

>AT117179 NZ_CP035088:c1550056-1549646 [Pseudomonas viciae]
ATGCTTTACCCGATTGCGATTTCCATGGGCGATGACAAGCACGCCTGGGGTGTTGAGGTGCCGGATATTCCCGGCTGTTT
TTCCGCTGGCGACGACCTGGACGAGGCCATGGCGATGGCACGTGAGGCCATTGAGGGGCACTTCGAGATTCTGGCTGAAG
ACGGTTCGCCGATTCCGTCGGCCAATACCGTCACCTTGCATGCAGCCAATCCAAAATATGCCGGCTGCACTTGGGCGCTG
GTGGACATTGATGTGACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACTTTGCCTGGCTACCTGCTCAATCGTAT
TGATGAATATGTGTTGCACCATCCTGAGGAAAAAAGCCGCTCAGGTTTTCTGGCTTCGGCGGCGCTGAAAGTGCTGCAGC
AGGGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References