Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 283780..284456 Replicon chromosome
Accession NZ_CP035088
Organism Pseudomonas viciae strain 11K1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EPZ47_RS01235 Protein ID WP_135843170.1
Coordinates 283780..283962 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EPZ47_RS01240 Protein ID WP_135847931.1
Coordinates 284055..284456 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPZ47_RS01220 279817..281778 + 1962 WP_178084290.1 choline transporter BetT -
EPZ47_RS01225 281902..282642 - 741 WP_135843168.1 SDR family oxidoreductase -
EPZ47_RS01230 282760..283650 + 891 WP_135843169.1 LysR family transcriptional regulator -
EPZ47_RS01235 283780..283962 + 183 WP_135843170.1 type II toxin-antitoxin system HicA family toxin Toxin
EPZ47_RS01240 284055..284456 + 402 WP_135847931.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EPZ47_RS01245 284522..285559 + 1038 WP_135843171.1 L-glyceraldehyde 3-phosphate reductase -
EPZ47_RS01250 285616..286458 - 843 WP_135843172.1 taurine dioxygenase -
EPZ47_RS01255 286509..287348 - 840 WP_135843173.1 taurine ABC transporter permease TauC -
EPZ47_RS01260 287345..288139 - 795 WP_135843174.1 taurine ABC transporter ATP-binding subunit -
EPZ47_RS01265 288165..289142 - 978 WP_135843175.1 taurine ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6871.99 Da        Isoelectric Point: 10.6627

>T117177 WP_135843170.1 NZ_CP035088:283780-283962 [Pseudomonas viciae]
MRSREMIRKIEEDGWYLVAVKGSHHQYKHSFKAGRVTIKHPDADLPKGTINSILKQAGLK

Download         Length: 183 bp

>T117177 NZ_CP035088:283780-283962 [Pseudomonas viciae]
ATGCGAAGTCGGGAAATGATCAGGAAGATCGAAGAGGACGGTTGGTATCTGGTGGCAGTCAAGGGTAGCCATCATCAGTA
CAAGCATTCCTTCAAGGCTGGGAGGGTGACGATCAAACACCCTGACGCCGACCTGCCGAAAGGTACGATTAATAGCATAT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14625.30 Da        Isoelectric Point: 4.4085

>AT117177 WP_135847931.1 NZ_CP035088:284055-284456 [Pseudomonas viciae]
MKFPVVLHKDADSEYGVTVPDVPGCFSAGSTVGQAFENVKEALSLHYEGLVADGEPLPQIHEIDDHLDNPDYAGGIWGVV
EFDVTPYFGKSVRFNATLPEQLLERIDQTVRRDQRYSSRSGFLAAAALRELSA

Download         Length: 402 bp

>AT117177 NZ_CP035088:284055-284456 [Pseudomonas viciae]
ATGAAATTTCCGGTCGTTCTGCACAAGGATGCCGATTCCGAATACGGAGTGACGGTCCCGGATGTGCCGGGTTGTTTCTC
CGCGGGCAGTACCGTGGGCCAGGCATTCGAAAATGTGAAGGAAGCGCTCTCGTTGCACTATGAAGGGCTGGTAGCCGACG
GCGAGCCGCTGCCGCAGATCCATGAAATTGACGATCATCTCGACAATCCGGATTACGCCGGAGGGATATGGGGTGTGGTT
GAGTTCGATGTCACGCCCTATTTCGGCAAGTCAGTGCGGTTCAACGCCACGCTGCCTGAGCAATTGCTTGAACGCATTGA
TCAAACCGTGCGACGTGATCAGCGCTACAGCTCCCGCTCGGGTTTTTTGGCGGCGGCTGCCTTGCGCGAACTTTCGGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References