117174

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2381653..2382332 Replicon chromosome
Accession NZ_CP035051
Organism Acinetobacter baumannii strain ABUH763

Toxin (Protein)


Gene name hicA Uniprot ID A0A7Z1VKH9
Locus tag EP552_RS11525 Protein ID WP_000838148.1
Coordinates 2382150..2382332 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag EP552_RS11520 Protein ID WP_000966688.1
Coordinates 2381653..2382057 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP552_RS11505 2377960..2379606 - 1647 WP_003383679.1 phosphoethanolamine--lipid A transferase -
EP552_RS11510 2379911..2380843 + 933 WP_001043692.1 IS5-like element ISAba13 family transposase -
EP552_RS11515 2381044..2381553 - 510 WP_000734512.1 hypothetical protein -
EP552_RS11520 2381653..2382057 - 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EP552_RS11525 2382150..2382332 - 183 WP_000838148.1 type II toxin-antitoxin system HicA family toxin Toxin
EP552_RS11535 2382658..2383173 - 516 WP_001185594.1 hypothetical protein -
EP552_RS11540 2383243..2384160 - 918 WP_000094259.1 hypothetical protein -
EP552_RS11545 2384213..2385178 - 966 WP_000002429.1 hypothetical protein -
EP552_RS11550 2385178..2385528 - 351 WP_000065011.1 hypothetical protein -
EP552_RS11555 2385597..2385995 - 399 WP_001251875.1 hypothetical protein -
EP552_RS11560 2385997..2386365 - 369 WP_000539750.1 hypothetical protein -
EP552_RS11565 2386337..2386744 - 408 WP_000247950.1 hypothetical protein -
EP552_RS11570 2386753..2387121 - 369 WP_002019566.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2379911..2415296 35385
- flank IS/Tn - - 2379911..2380843 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6677.82 Da        Isoelectric Point: 10.5523

>T117174 WP_000838148.1 NZ_CP035051:c2382332-2382150 [Acinetobacter baumannii]
VKSLDLIKMIEADSWYEVRVSGSHHHVKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T117174 NZ_CP035051:c2382332-2382150 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATAGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACGT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT117174 WP_000966688.1 NZ_CP035051:c2382057-2381653 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT117174 NZ_CP035051:c2382057-2381653 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z1VKH9

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References