Detailed information of TA system TA117173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1226812..1227491
• Replicon: chromosome
• Accession: NZ_CP035051
• Organism: Acinetobacter baumannii strain ABUH763

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7Z1VKH9
• Locus tag: EP552_RS05870
• Protein ID: WP_000838148.1
• Coordinates: 1226812..1226994 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: EP552_RS05875
• Protein ID: WP_000966688.1
• Coordinates: 1227087..1227491 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EP552_RS05825	1222023..1222391	+	369	WP_002019566.1	hypothetical protein	-
EP552_RS05830	1222400..1222807	+	408	WP_000247950.1	hypothetical protein	-
EP552_RS05835	1222779..1223147	+	369	WP_000539750.1	hypothetical protein	-
EP552_RS05840	1223149..1223547	+	399	WP_001251875.1	hypothetical protein	-
EP552_RS05845	1223616..1223966	+	351	WP_000065011.1	hypothetical protein	-
EP552_RS05850	1223966..1224931	+	966	WP_000002429.1	hypothetical protein	-
EP552_RS05855	1224984..1225901	+	918	WP_000094259.1	hypothetical protein	-
EP552_RS05860	1225971..1226486	+	516	WP_001185594.1	hypothetical protein	-
EP552_RS05870	1226812..1226994	+	183	WP_000838148.1	type II toxin-antitoxin system HicA family toxin	Toxin
EP552_RS05875	1227087..1227491	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EP552_RS05880	1227591..1228100	+	510	WP_000734512.1	hypothetical protein	-
EP552_RS05885	1228301..1229233	-	933	WP_001043692.1	IS5-like element ISAba13 family transposase	-
EP552_RS05890	1229538..1231184	+	1647	WP_000960799.1	phosphoethanolamine--lipid A transferase	-
EP552_RS19775	1231263..1231379	-	117	Protein_1121	SOS response-associated peptidase	-
EP552_RS05895	1231495..1231983	-	489	WP_000718101.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1194194..1233446	39252
	-	flank	IS/Tn	-	-	1228301..1229233	932

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6677.82 Da
• Isoelectric Point: 10.5523

>T117173 WP_000838148.1 NZ_CP035051:1226812-1226994 [Acinetobacter baumannii]
VKSLDLIKMIEADSWYEVRVSGSHHHVKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T117173 NZ_CP035051:1226812-1226994 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATAGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACGT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT117173 WP_000966688.1 NZ_CP035051:1227087-1227491 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT117173 NZ_CP035051:1227087-1227491 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: A0A7Z1VKH9

Antitoxin

• AlphaFold DB: N9L2H6