Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2328992..2329671 Replicon chromosome
Accession NZ_CP035049
Organism Acinetobacter baumannii strain ABUH773

Toxin (Protein)


Gene name hicA Uniprot ID A0A7Z1VKH9
Locus tag EQH48_RS11110 Protein ID WP_000838148.1
Coordinates 2329489..2329671 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag EQH48_RS11105 Protein ID WP_000966688.1
Coordinates 2328992..2329396 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH48_RS11090 2325299..2326945 - 1647 WP_003383679.1 phosphoethanolamine--lipid A transferase -
EQH48_RS11095 2327250..2328182 + 933 WP_001043692.1 IS5-like element ISAba13 family transposase -
EQH48_RS11100 2328383..2328892 - 510 WP_000734512.1 hypothetical protein -
EQH48_RS11105 2328992..2329396 - 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQH48_RS11110 2329489..2329671 - 183 WP_000838148.1 type II toxin-antitoxin system HicA family toxin Toxin
EQH48_RS11120 2329997..2330512 - 516 WP_001185594.1 hypothetical protein -
EQH48_RS11125 2330582..2331499 - 918 WP_000094259.1 hypothetical protein -
EQH48_RS11130 2331552..2332517 - 966 WP_000002429.1 hypothetical protein -
EQH48_RS11135 2332517..2332867 - 351 WP_000065011.1 hypothetical protein -
EQH48_RS11140 2332936..2333334 - 399 WP_001251875.1 hypothetical protein -
EQH48_RS11145 2333336..2333704 - 369 WP_000539750.1 hypothetical protein -
EQH48_RS11150 2333676..2334083 - 408 WP_000247950.1 hypothetical protein -
EQH48_RS11155 2334092..2334460 - 369 WP_002019566.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2327250..2362910 35660
- flank IS/Tn - - 2327250..2328182 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6677.82 Da        Isoelectric Point: 10.5523

>T117170 WP_000838148.1 NZ_CP035049:c2329671-2329489 [Acinetobacter baumannii]
VKSLDLIKMIEADSWYEVRVSGSHHHVKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T117170 NZ_CP035049:c2329671-2329489 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATAGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACGT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT117170 WP_000966688.1 NZ_CP035049:c2329396-2328992 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT117170 NZ_CP035049:c2329396-2328992 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z1VKH9

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References