Detailed information of TA system TA117165

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2506322..2507001
• Replicon: chromosome
• Accession: NZ_CP035045
• Organism: Acinetobacter baumannii strain ABUH793

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7Z1VKH9
• Locus tag: EP560_RS12245
• Protein ID: WP_000838148.1
• Coordinates: 2506819..2507001 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: EP560_RS12240
• Protein ID: WP_000966688.1
• Coordinates: 2506322..2506726 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EP560_RS12220	2501845..2502333	+	489	WP_000718101.1	hypothetical protein	-
EP560_RS20260	2502449..2502565	+	117	Protein_2361	SOS response-associated peptidase	-
EP560_RS12225	2502644..2504254	-	1611	Protein_2362	phosphoethanolamine--lipid A transferase	-
EP560_RS12230	2504586..2505515	+	930	Protein_2363	IS5-like element ISAba13 family transposase	-
EP560_RS12235	2505715..2506222	-	508	Protein_2364	hypothetical protein	-
EP560_RS12240	2506322..2506726	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EP560_RS12245	2506819..2507001	-	183	WP_000838148.1	type II toxin-antitoxin system HicA family toxin	Toxin
EP560_RS12255	2507325..2507839	-	515	Protein_2367	hypothetical protein	-
EP560_RS12260	2507908..2508824	-	917	Protein_2368	hypothetical protein	-
EP560_RS12265	2508874..2509836	-	963	Protein_2369	phage tail protein	-
EP560_RS12270	2509836..2510186	-	351	WP_000065011.1	hypothetical protein	-
EP560_RS12275	2510261..2510650	-	390	WP_213075463.1	hypothetical protein	-
EP560_RS12280	2510652..2511020	-	369	WP_000539750.1	hypothetical protein	-
EP560_RS12285	2510992..2511397	-	406	Protein_2373	hypothetical protein	-
EP560_RS12290	2511406..2511772	-	367	Protein_2374	glutamate 5-kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2498419..2539581	41162
	-	flank	IS/Tn	-	-	2505090..2505515	425

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6677.82 Da
• Isoelectric Point: 10.5523

>T117165 WP_000838148.1 NZ_CP035045:c2507001-2506819 [Acinetobacter baumannii]
VKSLDLIKMIEADSWYEVRVSGSHHHVKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T117165 NZ_CP035045:c2507001-2506819 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATAGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACGT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT117165 WP_000966688.1 NZ_CP035045:c2506726-2506322 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT117165 NZ_CP035045:c2506726-2506322 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: A0A7Z1VKH9

Antitoxin

• AlphaFold DB: N9L2H6