117164

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1364174..1364853 Replicon chromosome
Accession NZ_CP035045
Organism Acinetobacter baumannii strain ABUH793

Toxin (Protein)


Gene name hicA Uniprot ID A0A7Z1VKH9
Locus tag EP560_RS06655 Protein ID WP_000838148.1
Coordinates 1364174..1364356 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag EP560_RS06660 Protein ID WP_000966688.1
Coordinates 1364449..1364853 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP560_RS06610 1359385..1359753 + 369 WP_002019566.1 hypothetical protein -
EP560_RS06615 1359762..1360169 + 408 WP_000247950.1 hypothetical protein -
EP560_RS06620 1360141..1360509 + 369 WP_000539750.1 hypothetical protein -
EP560_RS06625 1360511..1360909 + 399 WP_001251875.1 hypothetical protein -
EP560_RS06630 1360978..1361328 + 351 WP_000065011.1 hypothetical protein -
EP560_RS06635 1361328..1362293 + 966 WP_000002429.1 hypothetical protein -
EP560_RS06640 1362346..1363263 + 918 WP_000094259.1 hypothetical protein -
EP560_RS06645 1363333..1363848 + 516 WP_001185594.1 hypothetical protein -
EP560_RS06655 1364174..1364356 + 183 WP_000838148.1 type II toxin-antitoxin system HicA family toxin Toxin
EP560_RS06660 1364449..1364853 + 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EP560_RS06665 1364953..1365462 + 510 WP_000734512.1 hypothetical protein -
EP560_RS06670 1365663..1366595 - 933 WP_001043692.1 IS5-like element ISAba13 family transposase -
EP560_RS06675 1366900..1368546 + 1647 WP_000960799.1 phosphoethanolamine--lipid A transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1336641..1370881 34240
- flank IS/Tn - - 1365663..1366595 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6677.82 Da        Isoelectric Point: 10.5523

>T117164 WP_000838148.1 NZ_CP035045:1364174-1364356 [Acinetobacter baumannii]
VKSLDLIKMIEADSWYEVRVSGSHHHVKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T117164 NZ_CP035045:1364174-1364356 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATAGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACGT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT117164 WP_000966688.1 NZ_CP035045:1364449-1364853 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT117164 NZ_CP035045:1364449-1364853 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z1VKH9

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References