Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 127748..128655 Replicon plasmid unnamed2
Accession NZ_CP035036
Organism Pantoea ananatis strain NN08200

Toxin (Protein)


Gene name - Uniprot ID D4GET9
Locus tag EPK90_RS23810 Protein ID WP_013027861.1
Coordinates 128188..128655 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A8A4JZ23
Locus tag EPK90_RS23805 Protein ID WP_014598335.1
Coordinates 127748..128191 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPK90_RS23775 122873..123259 - 387 WP_013027868.1 pyrimidine utilization protein C -
EPK90_RS23780 123285..124037 - 753 WP_019105823.1 pyrimidine utilization protein B -
EPK90_RS23785 124034..125125 - 1092 WP_013027866.1 pyrimidine utilization protein A -
EPK90_RS23790 125524..126213 + 690 WP_014598333.1 HTH-type transcriptional regulator RutR -
EPK90_RS23795 126288..126983 - 696 WP_014598334.1 hypothetical protein -
EPK90_RS23800 127137..127361 - 225 WP_013027863.1 KTSC domain-containing protein -
EPK90_RS23805 127748..128191 + 444 WP_014598335.1 DUF2384 domain-containing protein Antitoxin
EPK90_RS23810 128188..128655 + 468 WP_013027861.1 RES family NAD+ phosphorylase Toxin
EPK90_RS23815 129300..130694 + 1395 WP_128392654.1 flagellar filament capping protein FliD -
EPK90_RS23820 131379..132314 + 936 WP_013027859.1 hypothetical protein -
EPK90_RS23825 132376..132948 - 573 WP_014598338.1 NAD(P)H-dependent oxidoreductase -
EPK90_RS23830 133036..133269 + 234 WP_128392655.1 DUF333 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - vgrG/tssI / vgrG/tssI / icmF/tssM / tssF / tssG / fliC / fliC / vipA/tssB / vipB/tssC / vasE/tssK / dotU/tssL / hcp/tssD 1..307670 307670


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-145)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(31-89)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17207.70 Da        Isoelectric Point: 5.1570

>T117152 WP_013027861.1 NZ_CP035036:128188-128655 [Pantoea ananatis]
MKLYRMTKTRYLGSAWSGFGAREGGGRWNSVGVSMVYASETASLTMLETLIHLQSASVLDFFTLMSIDVPDRLIEWIDIK
QLPDDWAAPEAPAALRLFGDAWIQSGGSVALRVPSALSPVESNYLLNPEHPEFSAIVRQAVNIPFLFDARFSRQV

Download         Length: 468 bp

>T117152 NZ_CP035036:128188-128655 [Pantoea ananatis]
TTGAAGCTCTATCGCATGACCAAAACGCGCTATCTAGGGTCGGCCTGGAGCGGTTTTGGTGCCCGTGAAGGCGGCGGACG
CTGGAACAGCGTCGGCGTATCCATGGTCTACGCTTCTGAAACTGCTTCCCTCACCATGCTGGAGACGCTTATCCATCTGC
AAAGCGCCAGCGTACTGGACTTTTTTACCCTCATGAGCATTGACGTTCCCGACAGGCTGATTGAATGGATTGATATCAAG
CAACTGCCTGACGACTGGGCCGCACCGGAAGCGCCTGCAGCGCTGCGTTTATTTGGTGATGCCTGGATACAAAGCGGAGG
ATCGGTCGCACTTCGCGTGCCCAGTGCCCTTTCGCCCGTGGAATCGAATTATCTTCTCAATCCCGAGCATCCTGAATTCA
GTGCGATCGTCAGACAGGCAGTAAACATCCCCTTCCTTTTTGACGCACGCTTTTCCCGACAGGTATAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16375.69 Da        Isoelectric Point: 7.0208

>AT117152 WP_014598335.1 NZ_CP035036:127748-128191 [Pantoea ananatis]
MKQFTLPVSAAEPDRLWQFAGLSSADGVMLMDQIDDGLDGTVASRIVTWAQISQAELRRMTGIAGSTFTRGVKSRFTAEQ
SERLVRFIRVMDRAVELFEGDKEKARQWLNEPARALGNKKPADLVASETGAYEVLKLITRLEHGVYS

Download         Length: 444 bp

>AT117152 NZ_CP035036:127748-128191 [Pantoea ananatis]
ATGAAACAGTTCACTTTACCCGTATCCGCTGCAGAACCGGATCGTCTATGGCAATTTGCTGGCCTGAGCAGTGCTGACGG
CGTGATGCTGATGGATCAAATCGATGATGGTCTGGACGGTACGGTAGCCAGTCGCATTGTCACCTGGGCGCAAATCTCTC
AGGCAGAACTGCGCCGTATGACCGGCATTGCGGGCTCAACCTTCACCCGCGGCGTTAAAAGCCGCTTTACTGCGGAGCAG
AGCGAACGGCTGGTGCGTTTTATTCGCGTGATGGATCGTGCGGTTGAGCTGTTTGAGGGCGATAAAGAAAAGGCACGGCA
GTGGCTCAATGAGCCTGCGCGCGCCTTAGGCAATAAAAAACCGGCCGATCTGGTTGCGTCAGAAACCGGAGCTTATGAAG
TGCTGAAACTCATTACCCGGCTTGAACACGGTGTGTATTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References