Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 40161..40801 Replicon plasmid unnamed1
Accession NZ_CP035035
Organism Pantoea ananatis strain NN08200

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag EPK90_RS22770 Protein ID WP_128392536.1
Coordinates 40388..40801 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag EPK90_RS22765 Protein ID WP_128392535.1
Coordinates 40161..40391 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPK90_RS22735 35388..35618 + 231 WP_128392530.1 EexN family lipoprotein -
EPK90_RS22740 35756..36370 - 615 WP_128392613.1 DUF2971 domain-containing protein -
EPK90_RS22745 36683..37384 - 702 WP_128392531.1 hypothetical protein -
EPK90_RS22750 37584..38366 - 783 WP_128392532.1 site-specific integrase -
EPK90_RS22755 38400..39173 - 774 WP_128392533.1 hypothetical protein -
EPK90_RS22760 39227..39586 - 360 WP_128392534.1 hypothetical protein -
EPK90_RS22765 40161..40391 + 231 WP_128392535.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EPK90_RS22770 40388..40801 + 414 WP_128392536.1 type II toxin-antitoxin system VapC family toxin Toxin
EPK90_RS22775 41157..42026 - 870 WP_128392537.1 N-acetylmuramoyl-L-alanine amidase -
EPK90_RS22780 42056..42328 - 273 WP_128392614.1 helix-turn-helix transcriptional regulator -
EPK90_RS22785 42423..43172 - 750 WP_128392538.1 molecular chaperone -
EPK90_RS22790 43172..44458 - 1287 WP_128392539.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..125402 125402


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15024.36 Da        Isoelectric Point: 6.7054

>T117151 WP_128392536.1 NZ_CP035035:40388-40801 [Pantoea ananatis]
VNRTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVEEFCARPDAILPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLTLEDWV

Download         Length: 414 bp

>T117151 NZ_CP035035:40388-40801 [Pantoea ananatis]
GTGAACAGGACTTATATGCTGGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGCATCGTGGTCTCGGCCATTACTTACTCTGAAATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGTCACGTGCAGCTGGTCGAGGAATTCTGCGCCCGGCCCGATGCCATCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGCCTGGCCGGCACGCCGATCGGCCCGAACGACACGGCGATCGC
CGGACACGCCATCGCCGCCGGCGCCGTGCTGGTGACGAATAATGTGCGGGAGTTTGAGCGGGTGCCGGGTCTGACACTGG
AAGACTGGGTATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8679.79 Da        Isoelectric Point: 4.4563

>AT117151 WP_128392535.1 NZ_CP035035:40161-40391 [Pantoea ananatis]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMAERGDVVSDEGRFNL

Download         Length: 231 bp

>AT117151 NZ_CP035035:40161-40391 [Pantoea ananatis]
ATGAGAACCGTATCGATATTTAAAAACGGCAACAACCGTGCCATTCGTCTGCCCCGCGATCTGGATTTTGACGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTTG
AAAAAGCCGATCCGGACTTTATGGCGGAGCGCGGGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References