Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3587078..3587695 Replicon chromosome
Accession NZ_CP035034
Organism Pantoea ananatis strain NN08200

Toxin (Protein)


Gene name Hha Uniprot ID D4GLR0
Locus tag EPK90_RS17225 Protein ID WP_013024903.1
Coordinates 3587480..3587695 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8A4KA49
Locus tag EPK90_RS17220 Protein ID WP_015700827.1
Coordinates 3587078..3587455 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPK90_RS17190 3583360..3583614 + 255 WP_014606427.1 type B 50S ribosomal protein L31 -
EPK90_RS17195 3583626..3583766 + 141 WP_014606428.1 type B 50S ribosomal protein L36 -
EPK90_RS17200 3583826..3584703 - 878 Protein_3310 metal ABC transporter substrate-binding protein -
EPK90_RS17205 3584716..3585555 - 840 WP_013024907.1 metal ABC transporter permease -
EPK90_RS17210 3585552..3586223 - 672 WP_089517536.1 ATP-binding cassette domain-containing protein -
EPK90_RS17215 3586578..3586931 + 354 WP_013024905.1 hypothetical protein -
EPK90_RS17220 3587078..3587455 + 378 WP_015700827.1 Hha toxicity modulator TomB Antitoxin
EPK90_RS17225 3587480..3587695 + 216 WP_013024903.1 hemolysin expression modulator Hha Toxin
EPK90_RS17235 3588093..3588404 + 312 WP_014606432.1 MGMT family protein -
EPK90_RS17240 3588453..3589010 - 558 WP_019106636.1 YbaY family lipoprotein -
EPK90_RS17245 3589203..3590066 + 864 WP_116197519.1 acyl-CoA thioesterase II -
EPK90_RS17250 3590113..3591402 - 1290 WP_014606435.1 ammonium transporter AmtB -
EPK90_RS17255 3591437..3591775 - 339 WP_013024898.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8552.98 Da        Isoelectric Point: 9.4825

>T117150 WP_013024903.1 NZ_CP035034:3587480-3587695 [Pantoea ananatis]
MNKTLTKTDYLMRLRRCRSIDTLERVIEKNKYELPDEELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 216 bp

>T117150 NZ_CP035034:3587480-3587695 [Pantoea ananatis]
ATGAACAAAACCCTAACTAAAACTGATTATTTGATGCGACTGAGGCGCTGTCGTTCTATTGACACGCTGGAACGCGTGAT
TGAAAAAAATAAGTACGAATTACCCGATGAAGAATTAGCAGTATTTTACTCAGCAGCCGATCACCGCCTGGCTGAACTGA
CGATGAACAAGCTCTATGACAAAGTCCCGGTGTCAGTCTGGAAATTTGTACGCTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14722.35 Da        Isoelectric Point: 4.3976

>AT117150 WP_015700827.1 NZ_CP035034:3587078-3587455 [Pantoea ananatis]
MDEYSPKRHDIAQLKYLCENLFDDSMATLTDSHHGWVNDPTAESNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSNYSVNTQDLQRWQRSAKRLFNVFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT117150 NZ_CP035034:3587078-3587455 [Pantoea ananatis]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACTTGTGTGAGAATCTGTTTGACGACAGCATGGC
GACATTAACTGACAGTCATCACGGCTGGGTTAATGACCCCACTGCCGAAAGCAATTTACAGCTAAACGATTTGATTGAGC
ACATCGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGACGAAGCACTGATTACCCAAATCGATGAATATCTT
GATGATACCTTTATGCTGTTTAGCAACTACAGTGTAAATACTCAGGATCTTCAGCGCTGGCAACGCTCAGCGAAACGTTT
ATTTAATGTGTTTACTGAAGAGTGCGCTTTTCTTCAACAGCCAAGCCATTCATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References