Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2467299..2468647 Replicon chromosome
Accession NZ_CP035034
Organism Pantoea ananatis strain NN08200

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EPK90_RS11830 Protein ID WP_128392087.1
Coordinates 2467538..2468647 (+) Length 370 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EPK90_RS11825 Protein ID WP_014593756.1
Coordinates 2467299..2467538 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPK90_RS11810 2462891..2464279 + 1389 WP_014605798.1 MFS transporter -
EPK90_RS11815 2464302..2466677 + 2376 WP_128392086.1 glycoside hydrolase family 3 C-terminal domain-containing protein -
EPK90_RS11820 2466741..2467184 - 444 WP_126842947.1 GNAT family N-acetyltransferase -
EPK90_RS11825 2467299..2467538 + 240 WP_014593756.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EPK90_RS11830 2467538..2468647 + 1110 WP_128392087.1 HipA domain-containing protein Toxin
EPK90_RS11835 2468693..2469109 - 417 WP_013025826.1 GFA family protein -
EPK90_RS11840 2469315..2469497 - 183 WP_128392088.1 hypothetical protein -
EPK90_RS11845 2469560..2471428 - 1869 WP_013025825.1 low affinity potassium transporter Kup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(132-328)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 370 a.a.        Molecular weight: 40877.18 Da        Isoelectric Point: 7.4551

>T117149 WP_128392087.1 NZ_CP035034:2467538-2468647 [Pantoea ananatis]
MAKLIAWINGERTGTLTLHHNGALHFQYDANWLQHPLARPLSLSLPLQRAAMHSEKVVHFFENLLYPSALIEKDFYPTHP
IKSCEVFATLQKVGHTLPGALSLLPAKRQPVAPDQATHSVFSPADEAQQFDIDNAYLCLSLARELTIPVPDAVLVHENGI
RKLRTERYDRRWRHDGQHLYHLPEEDVCQALGVPLSGRDEQQGGPGIDDIMALLMGSSSAMKDREDLMRCLVFQWLTGIT
RVNAKHLSLLIARGGSFRLAPFKHLLSACPGLSLRTTDRRDFQLGMGLTGPEGKQHHIDAIGPAHFLALAGSVGFSQAAM
RQILAAFVPGLPAAIVKVRDSLPDDYPLTLADAVFSHAMMMLERVRQAI

Download         Length: 1110 bp

>T117149 NZ_CP035034:2467538-2468647 [Pantoea ananatis]
ATGGCAAAGCTCATTGCCTGGATAAACGGCGAGCGTACGGGAACGCTGACGCTGCATCACAACGGCGCGCTGCATTTCCA
GTATGACGCCAACTGGCTTCAGCATCCGCTTGCCAGACCTCTCTCGCTTTCGTTGCCCTTACAGCGCGCCGCGATGCATT
CTGAGAAAGTCGTGCACTTTTTCGAAAACCTTCTCTATCCCAGCGCGTTGATCGAAAAGGATTTTTACCCGACTCACCCG
ATAAAATCCTGTGAGGTCTTTGCAACATTGCAGAAAGTGGGACACACATTACCCGGGGCGCTCAGTCTGCTGCCGGCAAA
GCGGCAGCCCGTCGCGCCGGACCAGGCAACGCACAGCGTCTTCAGCCCCGCCGATGAGGCACAGCAGTTCGATATCGATA
ATGCGTATCTGTGTCTGTCCCTGGCCCGGGAGCTAACTATCCCGGTGCCGGATGCCGTGTTAGTTCATGAGAACGGCATC
CGTAAATTGAGAACAGAACGATACGATCGCCGTTGGCGTCACGACGGACAACACCTTTATCATCTTCCTGAAGAAGACGT
GTGTCAGGCGCTCGGCGTGCCGCTCTCTGGCCGCGATGAGCAGCAGGGCGGTCCGGGAATTGATGACATCATGGCCTTGC
TGATGGGCTCAAGCTCCGCCATGAAAGACCGTGAGGATCTGATGCGCTGTCTGGTATTTCAGTGGCTGACGGGCATCACG
CGCGTCAACGCTAAACATCTTTCGCTGCTGATTGCTCGCGGTGGCAGCTTCCGGCTCGCGCCTTTTAAGCATCTCCTTTC
CGCCTGCCCGGGCCTTTCTCTACGCACAACAGACAGACGGGATTTCCAGCTGGGGATGGGCCTGACAGGCCCTGAGGGCA
AACAGCATCACATTGACGCGATTGGGCCCGCGCATTTTCTTGCCCTTGCGGGGAGCGTGGGGTTCAGTCAGGCAGCGATG
CGGCAGATACTCGCGGCCTTTGTTCCGGGCTTGCCTGCCGCGATTGTTAAGGTGCGGGACAGCCTGCCCGATGATTATCC
CCTGACGCTCGCCGATGCGGTTTTCAGCCACGCAATGATGATGCTGGAAAGGGTGCGCCAGGCGATCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8790.95 Da        Isoelectric Point: 6.4540

>AT117149 WP_014593756.1 NZ_CP035034:2467299-2467538 [Pantoea ananatis]
MIYSPRQLANQVRLLRQQNGWTQVELAKKVGLKQATLSHFENAPDTTSLATLFKILQALDLALSLHENSASSAPDEDAW

Download         Length: 240 bp

>AT117149 NZ_CP035034:2467299-2467538 [Pantoea ananatis]
ATGATTTACAGTCCCCGCCAGTTGGCGAATCAGGTCAGGCTATTGCGGCAGCAAAACGGCTGGACCCAGGTCGAACTGGC
GAAAAAAGTGGGCCTGAAACAGGCAACCCTGTCTCACTTCGAAAATGCCCCGGATACAACCTCACTGGCAACGTTGTTCA
AAATCTTACAGGCGCTCGATCTTGCTCTGTCGCTTCATGAAAACAGCGCATCCTCAGCCCCGGATGAGGATGCCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References