Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1019943..1020568 Replicon chromosome
Accession NZ_CP035033
Organism Hydrogenovibrio thermophilus strain JR-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EPV75_RS04735 Protein ID WP_128384628.1
Coordinates 1020173..1020568 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag EPV75_RS04730 Protein ID WP_192894036.1
Coordinates 1019943..1020170 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPV75_RS04710 1015178..1016614 + 1437 WP_128384623.1 NADH-quinone oxidoreductase subunit NuoN -
EPV75_RS04715 1016667..1017005 + 339 WP_128384624.1 DUF2818 family protein -
EPV75_RS04720 1017136..1017909 + 774 WP_128384625.1 EAL domain-containing protein -
EPV75_RS04725 1018237..1019466 + 1230 WP_128384626.1 hypothetical protein -
EPV75_RS04730 1019943..1020170 + 228 WP_192894036.1 antitoxin Antitoxin
EPV75_RS04735 1020173..1020568 + 396 WP_128384628.1 type II toxin-antitoxin system VapC family toxin Toxin
EPV75_RS04745 1020892..1021428 - 537 WP_128384629.1 DUF2726 domain-containing protein -
EPV75_RS04750 1021664..1022251 + 588 WP_128384630.1 ANTAR domain-containing protein -
EPV75_RS04755 1022260..1023408 + 1149 WP_128384631.1 ABC transporter substrate-binding protein -
EPV75_RS04760 1023693..1025069 + 1377 WP_128385629.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14861.06 Da        Isoelectric Point: 4.9049

>T117138 WP_128384628.1 NZ_CP035033:1020173-1020568 [Hydrogenovibrio thermophilus]
MYVLDTNICIYIIKKQPPSVFEKFENLPLGSVSMSLVTFGELEYGAMRSNNSEKALNILDELINYIPVLPMGTNVAKHYA
DIRADLAKKGTLIGNNDLWIAAHTRSLDHTLVSNNIKEFERVESLEFENWV

Download         Length: 396 bp

>T117138 NZ_CP035033:1020173-1020568 [Hydrogenovibrio thermophilus]
ATGTATGTCCTTGATACCAATATCTGCATTTACATTATTAAAAAACAACCGCCTAGCGTTTTTGAAAAGTTCGAGAATTT
GCCTTTAGGTTCAGTCTCTATGTCATTAGTGACGTTTGGAGAGTTGGAATATGGAGCGATGAGAAGTAACAACTCAGAAA
AAGCACTGAATATTCTGGATGAATTGATTAACTATATTCCCGTTTTACCAATGGGAACCAATGTGGCCAAACACTATGCC
GATATACGAGCAGATTTAGCAAAAAAAGGAACGCTTATTGGCAATAATGATCTATGGATCGCCGCGCATACAAGGTCGCT
TGATCATACTTTAGTGAGTAATAACATTAAAGAATTTGAAAGAGTTGAAAGCCTTGAGTTTGAAAATTGGGTGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8645.87 Da        Isoelectric Point: 4.6437

>AT117138 WP_192894036.1 NZ_CP035033:1019943-1020170 [Hydrogenovibrio thermophilus]
MEARIFQSGNSQAVRIPKEFRFDVTEVEIFKRGDEIVLKPKPKNLGAAFKLLGEMPDDFMVDGREDTLPQERESF

Download         Length: 228 bp

>AT117138 NZ_CP035033:1019943-1020170 [Hydrogenovibrio thermophilus]
ATGGAAGCTAGAATTTTCCAATCCGGAAACAGTCAAGCCGTTAGAATTCCGAAAGAATTTCGTTTTGATGTCACGGAAGT
TGAAATCTTTAAGCGTGGCGATGAAATCGTTTTAAAGCCGAAACCCAAAAATTTAGGAGCCGCTTTTAAATTGCTTGGTG
AGATGCCAGACGATTTTATGGTTGATGGACGTGAAGACACCTTACCTCAAGAAAGAGAGTCTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References