117133

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1388215..1388691 Replicon chromosome
Accession NZ_CP035005
Organism Staphylococcus aureus strain PCFH-226

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag EMO94_RS07185 Protein ID WP_000052076.1
Coordinates 1388503..1388691 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EMO94_RS07180 Protein ID WP_001059690.1
Coordinates 1388215..1388475 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EMO94_RS07145 1383613..1384329 - 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -
EMO94_RS07150 1384477..1384899 + 423 WP_000974452.1 organic hydroperoxide resistance protein -
EMO94_RS07155 1385298..1385792 + 495 WP_000569881.1 GNAT family N-acetyltransferase -
EMO94_RS07160 1385941..1386558 + 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
EMO94_RS07165 1386631..1387212 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
EMO94_RS07170 1387437..1387673 + 237 WP_000368687.1 hypothetical protein -
EMO94_RS07175 1387670..1387873 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EMO94_RS07180 1388215..1388475 + 261 WP_001059690.1 hypothetical protein Antitoxin
EMO94_RS07185 1388503..1388691 + 189 WP_000052076.1 hypothetical protein Toxin
EMO94_RS07190 1388879..1389448 + 570 WP_001106655.1 hypothetical protein -
EMO94_RS07195 1389536..1389820 + 285 WP_001004403.1 hypothetical protein -
EMO94_RS07200 1389881..1390099 + 219 WP_000005881.1 hypothetical protein -
EMO94_RS07205 1390596..1390796 - 201 WP_001059082.1 cold-shock protein -
EMO94_RS07210 1391153..1391839 - 687 WP_128382690.1 thermonuclease family protein -
EMO94_RS07215 1392180..1392662 - 483 WP_000824489.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(8-67)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T117133 WP_000052076.1 NZ_CP035005:1388503-1388691 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T117133 NZ_CP035005:1388503-1388691 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT117133 WP_001059690.1 NZ_CP035005:1388215-1388475 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT117133 NZ_CP035005:1388215-1388475 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References