Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2456868..2457344 Replicon chromosome
Accession NZ_CP035003
Organism Staphylococcus aureus strain PCFA-221

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag EMO93_RS12370 Protein ID WP_000052076.1
Coordinates 2456868..2457056 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EMO93_RS12375 Protein ID WP_001059690.1
Coordinates 2457084..2457344 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EMO93_RS12340 2452479..2453651 + 1173 WP_000195429.1 IS256-like element IS256 family transposase -
EMO93_RS12345 2453720..2454406 + 687 WP_128382690.1 thermonuclease family protein -
EMO93_RS12350 2454763..2454963 + 201 WP_001059082.1 cold-shock protein -
EMO93_RS12355 2455460..2455678 - 219 WP_000005881.1 hypothetical protein -
EMO93_RS12360 2455739..2456023 - 285 WP_001004403.1 hypothetical protein -
EMO93_RS12365 2456111..2456680 - 570 WP_001106655.1 hypothetical protein -
EMO93_RS12370 2456868..2457056 - 189 WP_000052076.1 hypothetical protein Toxin
EMO93_RS12375 2457084..2457344 - 261 WP_001059690.1 hypothetical protein Antitoxin
EMO93_RS12380 2457686..2457889 + 204 WP_128382691.1 sterile alpha motif-like domain-containing protein -
EMO93_RS12385 2457886..2458122 - 237 WP_000368687.1 hypothetical protein -
EMO93_RS12390 2458347..2458928 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
EMO93_RS12395 2459001..2459618 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
EMO93_RS12400 2459767..2460261 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
EMO93_RS12405 2460660..2461082 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
EMO93_RS12410 2461230..2461946 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T117125 WP_000052076.1 NZ_CP035003:c2457056-2456868 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T117125 NZ_CP035003:c2457056-2456868 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT117125 WP_001059690.1 NZ_CP035003:c2457344-2457084 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT117125 NZ_CP035003:c2457344-2457084 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References