Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 815996..816603 Replicon plasmid pRapFH23d
Accession NZ_CP035002
Organism Rhizobium acidisoli strain FH23

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CO657_RS36400 Protein ID WP_054185826.1
Coordinates 816349..816603 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CO657_RS36395 Protein ID WP_054185827.1
Coordinates 815996..816352 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO657_RS36375 811248..812753 + 1506 WP_054185830.1 sugar ABC transporter ATP-binding protein -
CO657_RS36380 812750..813760 + 1011 WP_054185829.1 ABC transporter permease -
CO657_RS36385 813802..814779 + 978 WP_054185850.1 substrate-binding domain-containing protein -
CO657_RS36390 814846..815739 + 894 WP_054185828.1 amidohydrolase -
CO657_RS36395 815996..816352 - 357 WP_054185827.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CO657_RS36400 816349..816603 - 255 WP_054185826.1 type II toxin-antitoxin system HicA family toxin Toxin
CO657_RS36405 816728..817543 - 816 WP_054185825.1 MBL fold metallo-hydrolase -
CO657_RS36410 817588..818178 - 591 WP_054185824.1 SOS response-associated peptidase -
CO657_RS36415 818235..818732 + 498 WP_054185823.1 SOS response-associated peptidase -
CO657_RS36420 818729..819820 - 1092 WP_054185822.1 DNA polymerase IV -
CO657_RS36425 819817..820083 - 267 WP_082366377.1 hypothetical protein -
CO657_RS36430 820258..821019 + 762 WP_054185820.1 ImuA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - gmd 1..845857 845857


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9265.63 Da        Isoelectric Point: 9.8644

>T117117 WP_054185826.1 NZ_CP035002:c816603-816349 [Rhizobium acidisoli]
MNSKQRKTLAAVFTDPVSGTIEWAAIENLLVAAGADLIEGNGSRVKFEKDGIIASFHRPHPAKEAKRYQVRDAREFLMQI
GVTP

Download         Length: 255 bp

>T117117 NZ_CP035002:c816603-816349 [Rhizobium acidisoli]
ATGAACAGCAAGCAGAGAAAGACTCTCGCGGCGGTCTTCACGGACCCGGTCTCGGGAACCATTGAATGGGCCGCTATAGA
GAATCTGCTTGTGGCTGCCGGAGCCGACCTCATTGAGGGGAACGGTTCCCGCGTTAAGTTTGAAAAAGACGGGATCATTG
CGAGCTTCCATAGACCACATCCGGCCAAGGAAGCAAAGCGTTATCAGGTGCGCGATGCTCGCGAGTTCCTGATGCAGATT
GGAGTAACGCCATGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13288.93 Da        Isoelectric Point: 4.9838

>AT117117 WP_054185827.1 NZ_CP035002:c816352-815996 [Rhizobium acidisoli]
MNIMTYNGYHARIEFDAEDDVFFGRIAGISDVIGFHGDSVAELKKAFHEAVDDYLETCRKIGKEPQRPYSGKMMFRVAPE
VHRRAALAAELSGKSLNQWAEEVLEEAADHYAEARLPA

Download         Length: 357 bp

>AT117117 NZ_CP035002:c816352-815996 [Rhizobium acidisoli]
ATGAACATCATGACCTACAACGGATATCACGCTCGCATCGAATTCGACGCTGAGGACGATGTGTTTTTCGGCAGGATTGC
AGGTATCTCCGATGTAATCGGCTTTCACGGTGACAGTGTCGCTGAACTCAAGAAAGCCTTCCATGAGGCAGTCGATGACT
ACCTGGAGACCTGCAGGAAAATCGGCAAAGAGCCCCAGCGACCCTATTCTGGGAAGATGATGTTTCGTGTCGCTCCCGAA
GTCCATCGCCGAGCAGCTCTTGCTGCTGAGCTTTCGGGAAAGAGTCTGAACCAGTGGGCAGAAGAGGTGCTGGAAGAGGC
CGCCGACCATTATGCCGAGGCGCGCTTGCCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References