Detailed information of TA system TA117111

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4306034..4306623
• Replicon: chromosome
• Accession: NZ_CP034998
• Organism: Rhizobium acidisoli strain FH23

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B5ZW21
• Locus tag: CO657_RS20925
• Protein ID: WP_012559482.1
• Coordinates: 4306034..4306231 (+)
• Length: 66 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CO657_RS20930
• Protein ID: WP_054182204.1
• Coordinates: 4306228..4306623 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO657_RS20895	4301311..4301784	-	474	WP_003589362.1	hypothetical protein	-
CO657_RS20900	4301960..4302595	+	636	WP_003583389.1	trimeric intracellular cation channel family protein	-
CO657_RS20905	4302608..4303027	-	420	WP_003555773.1	transcriptional repressor	-
CO657_RS20910	4303328..4303843	+	516	WP_003589358.1	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA	-
CO657_RS20915	4303887..4305119	+	1233	WP_054182206.1	beta-ketoacyl-ACP synthase I	-
CO657_RS20920	4305124..4305930	+	807	WP_054182205.1	enoyl-ACP reductase FabI	-
CO657_RS20925	4306034..4306231	+	198	WP_012559482.1	type II toxin-antitoxin system HicA family toxin	Toxin
CO657_RS20930	4306228..4306623	+	396	WP_054182204.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CO657_RS20935	4306627..4307643	-	1017	WP_054182203.1	class I SAM-dependent methyltransferase	-
CO657_RS20940	4307773..4309911	-	2139	WP_003589352.1	polyribonucleotide nucleotidyltransferase	-
CO657_RS20945	4310268..4310537	-	270	WP_003571238.1	30S ribosomal protein S15	-
CO657_RS20950	4310691..4311542	-	852	WP_054182271.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7209.38 Da
• Isoelectric Point: 11.4650

>T117111 WP_012559482.1 NZ_CP034998:4306034-4306231 [Rhizobium acidisoli]
VERNSQKIIARLKREGFEIVSIKGSHHKLRRGNQTIIVPHPKKDLPIGTALAIAKQAGWNASDKS

Nucleotide

• Length: 198 bp

>T117111 NZ_CP034998:4306034-4306231 [Rhizobium acidisoli]
GTGGAGCGGAACAGTCAGAAGATCATCGCCAGGCTGAAGCGGGAGGGCTTCGAAATCGTTTCGATCAAGGGCTCGCACCA
CAAGCTTCGAAGAGGCAATCAAACCATCATCGTTCCGCACCCGAAGAAGGATCTGCCGATCGGCACGGCGCTTGCTATTG
CCAAGCAAGCCGGATGGAATGCGAGTGACAAATCATGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14445.23 Da
• Isoelectric Point: 4.3257

>AT117111 WP_054182204.1 NZ_CP034998:4306228-4306623 [Rhizobium acidisoli]
MKYFIALVHKDSDSAFGISFPDLPAVFSAADEEEDLTANAIETLRLWAEDETLPMPSSYDEISSRQDIREQLAAGAFLTR
VPFIEDATRTVRANVTFDKGMLEAIDKAAKERGLTRSAFLASAARKEIEAA

Nucleotide

• Length: 396 bp

>AT117111 NZ_CP034998:4306228-4306623 [Rhizobium acidisoli]
ATGAAATATTTCATTGCTCTCGTGCATAAGGACAGCGACAGCGCATTTGGGATCAGCTTTCCAGATCTGCCGGCGGTATT
TTCGGCCGCCGATGAGGAAGAAGACCTGACTGCCAACGCCATAGAAACCCTTCGCCTCTGGGCGGAAGATGAAACTTTGC
CGATGCCATCCTCATATGACGAGATCAGTTCTCGGCAGGATATCCGCGAGCAACTGGCTGCCGGTGCTTTCCTGACGCGT
GTTCCCTTTATCGAAGACGCCACGCGCACCGTTCGAGCCAATGTCACTTTCGACAAAGGCATGCTTGAGGCAATCGACAA
GGCCGCGAAAGAGCGCGGCCTGACCCGTTCGGCTTTCCTTGCAAGTGCGGCCCGCAAGGAAATCGAAGCCGCCTGA

Structures

Toxin

• AlphaFold DB: A0A0N1DMY0