Detailed information of TA system TA117073

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2806366..2807210
• Replicon: chromosome
• Accession: NZ_CP034958
• Organism: Escherichia coli strain SCEC020026

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: C7V14_RS14680
• Protein ID: WP_000854686.1
• Coordinates: 2806366..2806749 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0J1S3
• Locus tag: C7V14_RS14685
• Protein ID: WP_001285602.1
• Coordinates: 2806830..2807210 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7V14_RS14640	2801369..2801860	-	492	WP_001297187.1	DUF1097 domain-containing protein	-
C7V14_RS14645	2801962..2802516	-	555	WP_001001902.1	molecular chaperone YcdY	-
C7V14_RS14650	2802540..2803277	-	738	WP_000283664.1	zinc-binding phosphatase	-
C7V14_RS14655	2803332..2804270	-	939	WP_000351311.1	glyoxylate/hydroxypyruvate reductase GhrA	-
C7V14_RS14665	2804741..2805582	-	842	Protein_2648	DUF4942 domain-containing protein	-
C7V14_RS14670	2805667..2805864	-	198	WP_000839253.1	DUF957 domain-containing protein	-
C7V14_RS14675	2805881..2806369	-	489	WP_032180032.1	hypothetical protein	-
C7V14_RS14680	2806366..2806749	-	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
C7V14_RS14685	2806830..2807210	-	381	WP_001285602.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
C7V14_RS14690	2807221..2807904	-	684	WP_000086768.1	hypothetical protein	-
C7V14_RS14695	2807923..2808144	-	222	WP_000692298.1	DUF987 domain-containing protein	-
C7V14_RS14700	2808207..2808683	-	477	WP_001186726.1	RadC family protein	-
C7V14_RS14705	2808699..2809184	-	486	WP_000214307.1	antirestriction protein	-
C7V14_RS14710	2809276..2810097	-	822	WP_001761104.1	DUF945 domain-containing protein	-
C7V14_RS14720	2810198..2810406	-	209	Protein_2658	DUF905 family protein	-
C7V14_RS14725	2810507..2810962	-	456	WP_000581506.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T117073 WP_000854686.1 NZ_CP034958:c2806749-2806366 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T117073 NZ_CP034958:c2806749-2806366 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13938.69 Da
• Isoelectric Point: 5.0823

>AT117073 WP_001285602.1 NZ_CP034958:c2807210-2806830 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT117073 NZ_CP034958:c2807210-2806830 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG