Detailed information of TA system TA117046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3896177..3896991
• Replicon: chromosome
• Accession: NZ_CP034953
• Organism: Escherichia coli strain MT102

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: EPB33_RS18970
• Protein ID: WP_001054376.1
• Coordinates: 3896177..3896434 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: EPB33_RS18975
• Protein ID: WP_001309181.1
• Coordinates: 3896446..3896991 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EPB33_RS18950	3891465..3892571	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
EPB33_RS18955	3892636..3893616	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
EPB33_RS18960	3894199..3895439	-	1241	Protein_3698	helicase YjhR	-
EPB33_RS18965	3895555..3895800	+	246	Protein_3699	GNAT family N-acetyltransferase	-
EPB33_RS18970	3896177..3896434	+	258	WP_001054376.1	hypothetical protein	Toxin
EPB33_RS18975	3896446..3896991	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
EPB33_RS18980	3897047..3897793	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
EPB33_RS18985	3897962..3898180	+	219	Protein_3703	hypothetical protein	-
EPB33_RS22330	3898218..3898334	+	117	Protein_3704	VOC family protein	-
EPB33_RS18990	3898579..3899700	+	1122	WP_000010829.1	M42 family metallopeptidase	-
EPB33_RS18995	3899697..3899975	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
EPB33_RS19000	3899987..3901300	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	3885963..3905215	19252

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T117046 WP_001054376.1 NZ_CP034953:3896177-3896434 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T117046 NZ_CP034953:3896177-3896434 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT117046 WP_001309181.1 NZ_CP034953:3896446-3896991 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT117046 NZ_CP034953:3896446-3896991 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8