Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2236562..2237088 | Replicon | chromosome |
| Accession | NZ_CP034953 | ||
| Organism | Escherichia coli strain MT102 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | EPB33_RS10835 | Protein ID | WP_000323025.1 |
| Coordinates | 2236801..2237088 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | EPB33_RS10830 | Protein ID | WP_000534858.1 |
| Coordinates | 2236562..2236801 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EPB33_RS10770 | 2231589..2232356 | - | 768 | Protein_2101 | exonuclease | - |
| EPB33_RS10775 | 2232449..2232640 | - | 192 | WP_001083297.1 | lysis protein YdfD | - |
| EPB33_RS10780 | 2232637..2232825 | - | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| EPB33_RS10790 | 2233393..2233611 | - | 219 | WP_001171942.1 | hypothetical protein | - |
| EPB33_RS10795 | 2233771..2233926 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
| EPB33_RS10800 | 2234093..2234500 | - | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| EPB33_RS10805 | 2234584..2234814 | + | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| EPB33_RS10810 | 2234798..2235076 | + | 279 | Protein_2108 | hypothetical protein | - |
| EPB33_RS10815 | 2235111..2235260 | + | 150 | WP_011443592.1 | hypothetical protein | - |
| EPB33_RS10820 | 2235697..2236029 | - | 333 | WP_001301033.1 | protein FlxA | - |
| EPB33_RS10825 | 2236232..2236537 | - | 306 | WP_001326990.1 | hypothetical protein | - |
| EPB33_RS10830 | 2236562..2236801 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| EPB33_RS10835 | 2236801..2237088 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| EPB33_RS10840 | 2237160..2237315 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| EPB33_RS10845 | 2237532..2237783 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| EPB33_RS10850 | 2237850..2238128 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| EPB33_RS10855 | 2238130..2239179 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| EPB33_RS10860 | 2239193..2239945 | + | 753 | WP_001047135.1 | antitermination protein | - |
| EPB33_RS10865 | 2240223..2240312 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| EPB33_RS10870 | 2240367..2240579 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| EPB33_RS10875 | 2240880..2241095 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| EPB33_RS22245 | 2241459..2241629 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| EPB33_RS10880 | 2241849..2242064 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2228390..2262445 | 34055 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T117037 WP_000323025.1 NZ_CP034953:2236801-2237088 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T117037 NZ_CP034953:2236801-2237088 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT117037 WP_000534858.1 NZ_CP034953:2236562-2236801 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT117037 NZ_CP034953:2236562-2236801 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|