Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2606586..2607173 Replicon chromosome
Accession NZ_CP034951
Organism Aequorivita sp. H23M31

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag EI546_RS11465 Protein ID WP_128250666.1
Coordinates 2606874..2607173 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EI546_RS11460 Protein ID WP_128250665.1
Coordinates 2606586..2606870 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EI546_RS11440 2602266..2602667 - 402 WP_128250662.1 hypothetical protein -
EI546_RS11445 2603296..2603622 - 327 WP_128250663.1 ATP-binding cassette domain-containing protein -
EI546_RS11450 2603956..2604422 - 467 Protein_2269 RDD family protein -
EI546_RS11455 2604518..2605828 - 1311 Protein_2270 IS110 family transposase -
EI546_RS11460 2606586..2606870 - 285 WP_128250665.1 putative addiction module antidote protein Antitoxin
EI546_RS11465 2606874..2607173 - 300 WP_128250666.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EI546_RS11470 2607626..2608651 + 1026 Protein_2273 IS110 family transposase -
EI546_RS11475 2608811..2609020 - 210 WP_128250667.1 helix-turn-helix transcriptional regulator -
EI546_RS11480 2609024..2609521 - 498 WP_128250668.1 DUF2975 domain-containing protein -
EI546_RS11485 2609747..2610037 - 291 WP_128251605.1 helix-turn-helix transcriptional regulator -
EI546_RS11490 2610027..2610383 - 357 WP_128250669.1 type II toxin-antitoxin system RelE/ParE family toxin -
EI546_RS11495 2610542..2611852 - 1311 Protein_2278 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11651.73 Da        Isoelectric Point: 10.4236

>T117016 WP_128250666.1 NZ_CP034951:c2607173-2606874 [Aequorivita sp. H23M31]
MFFIEKTSEFDKWLKKLKDFRAKAKIIFRIQKLETDEHFGDCKPVGDGIQEMRINLAKGYRVYFKEKDGKIIVLLIGGDK
STQQKDIAQAKNIWKKLNK

Download         Length: 300 bp

>T117016 NZ_CP034951:c2607173-2606874 [Aequorivita sp. H23M31]
ATGTTCTTCATTGAGAAAACATCTGAATTTGATAAATGGCTAAAAAAGTTAAAAGACTTTAGGGCTAAGGCTAAAATAAT
TTTCAGAATTCAGAAATTGGAAACTGACGAGCATTTTGGCGATTGCAAACCCGTGGGCGATGGAATACAGGAAATGCGAA
TAAATTTAGCTAAGGGTTACCGTGTTTACTTCAAAGAAAAAGATGGAAAAATTATTGTTCTTTTGATAGGAGGAGATAAA
TCGACCCAGCAAAAGGACATTGCACAAGCAAAGAACATTTGGAAAAAATTAAACAAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10045.52 Da        Isoelectric Point: 4.7205

>AT117016 WP_128250665.1 NZ_CP034951:c2606870-2606586 [Aequorivita sp. H23M31]
MGTSKFEIADYLDSKEMIAEYLNTVLEDGDNSDIINAIGHVAKAIGMTKIAEETGLSRPSLYKALSDGAKPQFATIMKVL
KAIGGQIQVNPTSV

Download         Length: 285 bp

>AT117016 NZ_CP034951:c2606870-2606586 [Aequorivita sp. H23M31]
ATGGGAACTTCAAAATTTGAAATAGCGGATTATCTAGACAGTAAAGAAATGATTGCAGAATATCTCAACACTGTTCTGGA
AGATGGTGATAACTCAGATATTATTAATGCAATAGGACACGTTGCTAAAGCCATCGGAATGACAAAAATAGCGGAGGAAA
CTGGATTAAGCCGTCCGAGTTTATATAAAGCATTATCTGATGGAGCAAAACCTCAATTTGCTACAATTATGAAAGTATTA
AAAGCAATTGGAGGACAAATACAAGTGAATCCTACATCTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References