Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3723576..3724393 Replicon chromosome
Accession NZ_CP034944
Organism Morganella morganii subsp. morganii strain ATCC 25830

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A2C5TM43
Locus tag EO986_RS17840 Protein ID WP_004236532.1
Coordinates 3723576..3724058 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID J7TDK6
Locus tag EO986_RS17845 Protein ID WP_004236533.1
Coordinates 3724085..3724393 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EO986_RS17810 3718940..3719563 - 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -
EO986_RS17815 3719582..3720577 - 996 WP_004236526.1 serine/threonine protein kinase -
EO986_RS17820 3720577..3720846 - 270 WP_004240741.1 YihD family protein -
EO986_RS17825 3721049..3722164 + 1116 WP_004236528.1 molybdenum cofactor guanylyltransferase MobA -
EO986_RS17830 3722374..3722676 + 303 WP_004236529.1 ABC transporter substrate-binding protein -
EO986_RS17835 3722804..3723325 + 522 WP_015422407.1 isopentenyl-diphosphate Delta-isomerase -
EO986_RS18770 3723322..3723462 + 141 WP_004236531.1 hypothetical protein -
EO986_RS17840 3723576..3724058 - 483 WP_004236532.1 GNAT family N-acetyltransferase Toxin
EO986_RS17845 3724085..3724393 - 309 WP_004236533.1 DUF1778 domain-containing protein Antitoxin
EO986_RS17850 3724525..3725877 - 1353 WP_004236534.1 glutathione-disulfide reductase -
EO986_RS17855 3725947..3726789 - 843 WP_004236535.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
EO986_RS17860 3726979..3727368 + 390 WP_004236536.1 DUF1090 domain-containing protein -
EO986_RS17865 3727780..3728772 + 993 WP_004236539.1 inner membrane protein YhjD -
EO986_RS17870 3728880..3729086 + 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(36-135)

Antitoxin

Vibrio phage ICP1, Orf50

(21-94)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17729.48 Da        Isoelectric Point: 10.2370

>T117013 WP_004236532.1 NZ_CP034944:c3724058-3723576 [Morganella morganii subsp. morganii]
MQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPEIPVILPGR
LAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQLATGIYSE

Download         Length: 483 bp

>T117013 NZ_CP034944:c3724058-3723576 [Morganella morganii subsp. morganii]
TTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCATTGGCTGAAAACCCGCGCATTGCA
AAATCAGCAATCCGGAGCCTCACGGACATTTGTCGTCTGCCACCATAACCGGATAATGGCCTATTATGCATTATCGACAG
GCGTTATTACCTGTTCACAGGCGGCGGGTCGTTTCAGACGTAATATGCCCCCGGAAATTCCGGTTATCCTGCCGGGACGT
CTTGCTGTTGACGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGATGCCGCACTGCGGGTCTTGCAGGC
GGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCAGACGTTTTTATGAGCATACCGGTT
TTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAGCTGGCAACCGGCATCTATTCTGAA
TAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11499.15 Da        Isoelectric Point: 8.6397

>AT117013 WP_004236533.1 NZ_CP034944:c3724393-3724085 [Morganella morganii subsp. morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Download         Length: 309 bp

>AT117013 NZ_CP034944:c3724393-3724085 [Morganella morganii subsp. morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGACGAAGGCGCCGTGGGAGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C5TM43

Antitoxin

Source ID Structure
AlphaFold DB J7TDK6

References