Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
Location | 1318292..1319208 | Replicon | chromosome |
Accession | NZ_CP034943 | ||
Organism | Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499 strain ATCC 6633 |
Toxin (Protein)
Gene name | spoIISA | Uniprot ID | - |
Locus tag | EO946_RS06900 | Protein ID | WP_003218453.1 |
Coordinates | 1318462..1319208 (-) | Length | 249 a.a. |
Antitoxin (Protein)
Gene name | spoIISB | Uniprot ID | - |
Locus tag | EO946_RS06895 | Protein ID | WP_003218451.1 |
Coordinates | 1318292..1318462 (-) | Length | 57 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EO946_RS06860 | 1315156..1315482 | + | 327 | WP_003218439.1 | XkdW family protein | - |
EO946_RS06865 | 1315479..1315643 | + | 165 | WP_003218441.1 | XkdX family protein | - |
EO946_RS06870 | 1315688..1316527 | + | 840 | WP_003218443.1 | hypothetical protein | - |
EO946_RS06875 | 1316580..1316849 | + | 270 | WP_003218444.1 | hemolysin XhlA family protein | - |
EO946_RS06880 | 1316862..1317125 | + | 264 | WP_003218447.1 | phage holin | - |
EO946_RS06885 | 1317138..1318031 | + | 894 | WP_003218449.1 | N-acetylmuramoyl-L-alanine amidase | - |
EO946_RS06890 | 1318069..1318206 | - | 138 | WP_136654612.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISC | - |
EO946_RS06895 | 1318292..1318462 | - | 171 | WP_003218451.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISB | Antitoxin |
EO946_RS06900 | 1318462..1319208 | - | 747 | WP_003218453.1 | toxin-antitoxin-antitoxin system toxin SpoIISA | Toxin |
EO946_RS06905 | 1319318..1320319 | - | 1002 | WP_003218455.1 | inorganic phosphate transporter | - |
EO946_RS06910 | 1320332..1320949 | - | 618 | WP_003218470.1 | DUF47 domain-containing protein | - |
EO946_RS06915 | 1321226..1322542 | - | 1317 | WP_003218471.1 | serine/threonine exchanger | - |
EO946_RS06920 | 1322925..1323875 | + | 951 | WP_003218472.1 | ring-cleaving dioxygenase | - |
EO946_RS06925 | 1323976..1324122 | + | 147 | WP_003218473.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29067.56 Da Isoelectric Point: 4.6878
>T117011 WP_003218453.1 NZ_CP034943:c1319208-1318462 [Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499]
MLLFFQIMVWCIMAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYDSSSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKNRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFIIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
MLLFFQIMVWCIMAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYDSSSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKNRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFIIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
Download Length: 747 bp
>T117011 NZ_CP034943:c1319208-1318462 [Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499]
ATGCTTTTATTCTTTCAGATCATGGTCTGGTGCATCATGGCCGGATTGGGCTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCTATCCGGAAAACATGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGATTCCTCTTCCCTGTTTACTCACTGGGAACGGTATCTCATTGTCGCCGTCAGTTTTGCTTTAATTGACGCTTTC
ATCTTCTTAAGCGCATACGTCAAAAAACTGGCCGGCAGCGAACTGGAAACAGACACAAGAGAAATTCTCGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCACGTTTATTATG
GAAGTATAGAAGCATATGCTGAAGGTATTGATAAACTGCTGAAAACCTATGCCGATAAAATGAACTTAACGGCCTCCCTT
TGTCACTATTCGACACAGGCTGATAAAAACCGGTTAACAGAGCATATGGACGATCCGGCAGACGTGCAAACTCGTCTTGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTATCATCGAGACACAGAGTTACGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTTTTCACATCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA
ATGCTTTTATTCTTTCAGATCATGGTCTGGTGCATCATGGCCGGATTGGGCTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCTATCCGGAAAACATGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGATTCCTCTTCCCTGTTTACTCACTGGGAACGGTATCTCATTGTCGCCGTCAGTTTTGCTTTAATTGACGCTTTC
ATCTTCTTAAGCGCATACGTCAAAAAACTGGCCGGCAGCGAACTGGAAACAGACACAAGAGAAATTCTCGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCACGTTTATTATG
GAAGTATAGAAGCATATGCTGAAGGTATTGATAAACTGCTGAAAACCTATGCCGATAAAATGAACTTAACGGCCTCCCTT
TGTCACTATTCGACACAGGCTGATAAAAACCGGTTAACAGAGCATATGGACGATCCGGCAGACGTGCAAACTCGTCTTGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTATCATCGAGACACAGAGTTACGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTTTTCACATCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6545.55 Da Isoelectric Point: 10.8401
>AT117011 WP_003218451.1 NZ_CP034943:c1318462-1318292 [Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499]
MERAFQNGCEPRAAKSFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
MERAFQNGCEPRAAKSFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
Download Length: 171 bp
>AT117011 NZ_CP034943:c1318462-1318292 [Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499]
ATGGAACGCGCATTTCAAAACGGATGCGAGCCCCGCGCGGCGAAGTCGTTTAAAATCCTGAAGAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGCCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA
ATGGAACGCGCATTTCAAAACGGATGCGAGCCCCGCGCGGCGAAGTCGTTTAAAATCCTGAAGAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGCCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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