Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1318292..1319208 Replicon chromosome
Accession NZ_CP034943
Organism Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499 strain ATCC 6633

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag EO946_RS06900 Protein ID WP_003218453.1
Coordinates 1318462..1319208 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID -
Locus tag EO946_RS06895 Protein ID WP_003218451.1
Coordinates 1318292..1318462 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EO946_RS06860 1315156..1315482 + 327 WP_003218439.1 XkdW family protein -
EO946_RS06865 1315479..1315643 + 165 WP_003218441.1 XkdX family protein -
EO946_RS06870 1315688..1316527 + 840 WP_003218443.1 hypothetical protein -
EO946_RS06875 1316580..1316849 + 270 WP_003218444.1 hemolysin XhlA family protein -
EO946_RS06880 1316862..1317125 + 264 WP_003218447.1 phage holin -
EO946_RS06885 1317138..1318031 + 894 WP_003218449.1 N-acetylmuramoyl-L-alanine amidase -
EO946_RS06890 1318069..1318206 - 138 WP_136654612.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
EO946_RS06895 1318292..1318462 - 171 WP_003218451.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
EO946_RS06900 1318462..1319208 - 747 WP_003218453.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
EO946_RS06905 1319318..1320319 - 1002 WP_003218455.1 inorganic phosphate transporter -
EO946_RS06910 1320332..1320949 - 618 WP_003218470.1 DUF47 domain-containing protein -
EO946_RS06915 1321226..1322542 - 1317 WP_003218471.1 serine/threonine exchanger -
EO946_RS06920 1322925..1323875 + 951 WP_003218472.1 ring-cleaving dioxygenase -
EO946_RS06925 1323976..1324122 + 147 WP_003218473.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29067.56 Da        Isoelectric Point: 4.6878

>T117011 WP_003218453.1 NZ_CP034943:c1319208-1318462 [Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499]
MLLFFQIMVWCIMAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYDSSSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKNRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFIIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

>T117011 NZ_CP034943:c1319208-1318462 [Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499]
ATGCTTTTATTCTTTCAGATCATGGTCTGGTGCATCATGGCCGGATTGGGCTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCTATCCGGAAAACATGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGATTCCTCTTCCCTGTTTACTCACTGGGAACGGTATCTCATTGTCGCCGTCAGTTTTGCTTTAATTGACGCTTTC
ATCTTCTTAAGCGCATACGTCAAAAAACTGGCCGGCAGCGAACTGGAAACAGACACAAGAGAAATTCTCGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCACGTTTATTATG
GAAGTATAGAAGCATATGCTGAAGGTATTGATAAACTGCTGAAAACCTATGCCGATAAAATGAACTTAACGGCCTCCCTT
TGTCACTATTCGACACAGGCTGATAAAAACCGGTTAACAGAGCATATGGACGATCCGGCAGACGTGCAAACTCGTCTTGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTATCATCGAGACACAGAGTTACGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTTTTCACATCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6545.55 Da        Isoelectric Point: 10.8401

>AT117011 WP_003218451.1 NZ_CP034943:c1318462-1318292 [Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499]
MERAFQNGCEPRAAKSFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp

>AT117011 NZ_CP034943:c1318462-1318292 [Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499]
ATGGAACGCGCATTTCAAAACGGATGCGAGCCCCGCGCGGCGAAGTCGTTTAAAATCCTGAAGAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGCCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References