Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1888572..1889206 Replicon chromosome
Accession NZ_CP034938
Organism Pectobacterium odoriferum strain JK2.1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EO763_RS08375 Protein ID WP_161528673.1
Coordinates 1888802..1889206 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EO763_RS08370 Protein ID WP_132455036.1
Coordinates 1888572..1888802 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EO763_RS23260 1884618..1884776 + 159 WP_154715508.1 hypothetical protein -
EO763_RS08340 1884923..1885756 + 834 WP_161528668.1 hypothetical protein -
EO763_RS08345 1885813..1886163 + 351 WP_116156686.1 hypothetical protein -
EO763_RS08350 1886291..1886764 + 474 WP_161528669.1 DNA repair protein RadC -
EO763_RS08355 1886804..1887139 + 336 WP_161528670.1 type IV toxin-antitoxin system YeeU family antitoxin -
EO763_RS08360 1887207..1887527 + 321 WP_161528671.1 TA system toxin CbtA family protein -
EO763_RS08365 1887645..1888478 + 834 WP_161528672.1 DUF4942 domain-containing protein -
EO763_RS08370 1888572..1888802 + 231 WP_132455036.1 antitoxin Antitoxin
EO763_RS08375 1888802..1889206 + 405 WP_161528673.1 tRNA(fMet)-specific endonuclease VapC Toxin
EO763_RS08380 1889512..1889751 - 240 Protein_1631 integrase -
EO763_RS08385 1889810..1890685 - 876 WP_161528674.1 HNH endonuclease -
EO763_RS08390 1890774..1891319 - 546 WP_161528675.1 transcriptional regulator -
EO763_RS08395 1891371..1892825 - 1455 WP_161528676.1 flagellin -
EO763_RS08400 1893760..1894023 + 264 WP_161528677.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1872073..1895037 22964


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15029.26 Da        Isoelectric Point: 8.0253

>T117003 WP_161528673.1 NZ_CP034938:1888802-1889206 [Pectobacterium odoriferum]
MLKYLLDTNICIYTIKNKPQEVRDAFYRHYGQFAISAITLMELIYGAEKSVNPEKNLAVIEGFSARLEVQTYGFDAAVHT
GQIRAELARQGTPIGPYDAMLAGHARSAGLILVTNNVREFERVPGLRVENWVGR

Download         Length: 405 bp

>T117003 NZ_CP034938:1888802-1889206 [Pectobacterium odoriferum]
ATGCTGAAATATCTGCTCGATACCAATATCTGTATTTACACCATCAAGAACAAACCGCAGGAAGTCAGGGACGCTTTCTA
CCGCCATTACGGGCAGTTTGCTATCAGTGCTATCACGCTGATGGAGCTGATTTACGGCGCGGAGAAATCGGTAAACCCAG
AAAAGAATCTCGCCGTGATTGAAGGGTTTTCTGCGCGTCTGGAAGTGCAAACTTATGGCTTTGACGCTGCCGTACATACG
GGGCAAATTCGTGCGGAACTGGCAAGACAAGGAACCCCCATCGGCCCGTATGATGCCATGTTAGCTGGTCATGCGCGGTC
CGCAGGTTTGATTCTGGTAACGAACAATGTGCGTGAGTTTGAGCGTGTGCCAGGATTGCGCGTAGAAAACTGGGTCGGTA
GATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8680.72 Da        Isoelectric Point: 4.3063

>AT117003 WP_132455036.1 NZ_CP034938:1888572-1888802 [Pectobacterium odoriferum]
MEKTTVFKSNRSQAVRLPKAVALPDDVKQVDIVAIGRTRIITPAGESWDSWFEEDGVTPDFMITREQPDDQVREDF

Download         Length: 231 bp

>AT117003 NZ_CP034938:1888572-1888802 [Pectobacterium odoriferum]
ATGGAAAAAACCACAGTATTTAAAAGCAATCGCAGCCAGGCGGTACGACTCCCTAAAGCCGTTGCGCTGCCCGATGATGT
GAAGCAGGTTGATATCGTTGCGATTGGTCGCACACGTATCATTACTCCGGCAGGCGAAAGCTGGGACAGTTGGTTCGAAG
AAGATGGAGTAACACCTGACTTCATGATCACCAGAGAGCAACCCGATGATCAGGTCAGGGAAGATTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References