Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1388510..1389135 Replicon chromosome
Accession NZ_CP034938
Organism Pectobacterium odoriferum strain JK2.1

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag EO763_RS06120 Protein ID WP_005976087.1
Coordinates 1388510..1388713 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag EO763_RS06125 Protein ID WP_005976089.1
Coordinates 1388767..1389135 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EO763_RS06090 1383969..1384307 + 339 WP_002208627.1 P-II family nitrogen regulator -
EO763_RS06095 1384347..1385633 + 1287 WP_039490511.1 ammonium transporter AmtB -
EO763_RS06100 1385766..1386629 - 864 WP_010303014.1 acyl-CoA thioesterase II -
EO763_RS06105 1386842..1387423 + 582 WP_039490514.1 YbaY family lipoprotein -
EO763_RS06110 1387443..1387763 - 321 WP_015839360.1 MGMT family protein -
EO763_RS06120 1388510..1388713 - 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
EO763_RS06125 1388767..1389135 - 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
EO763_RS06130 1389857..1390000 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
EO763_RS06135 1390018..1390266 - 249 WP_039506474.1 type B 50S ribosomal protein L31 -
EO763_RS06140 1390499..1393626 - 3128 Protein_1198 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T117000 WP_005976087.1 NZ_CP034938:c1388713-1388510 [Pectobacterium odoriferum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T117000 NZ_CP034938:c1388713-1388510 [Pectobacterium odoriferum]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCTAATGATGAACTGGAGATGTTCTTTTCCGCAGCCGATCATCGTCTGGCTGAACTGACAATGAACAAAC
TCTACGACAAAGTTCCTACCGCAGTATGGCGATACGTCCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT117000 WP_005976089.1 NZ_CP034938:c1389135-1388767 [Pectobacterium odoriferum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT117000 NZ_CP034938:c1389135-1388767 [Pectobacterium odoriferum]
ATGGATGAGTACACACCAAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGACGAAAGCATAGC
AACGTTAGGTGATAGCAGTCACGGCTGGGTCAATGATCCAACATCTGCGATCAATCTCCAATTAAATGAACTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAGTATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGAATTAATGATGCTGAACTGCGGCGTTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References