Detailed information of TA system TA116993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 169324..169958
• Replicon: chromosome
• Accession: NZ_CP034938
• Organism: Pectobacterium odoriferum strain JK2.1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EO763_RS00720
• Protein ID: WP_161527778.1
• Coordinates: 169683..169958 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A094S1G3
• Locus tag: EO763_RS00715
• Protein ID: WP_039491883.1
• Coordinates: 169324..169686 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EO763_RS00710	165321..169064	-	3744	WP_161527777.1	DUF4132 domain-containing protein	-
EO763_RS00715	169324..169686	-	363	WP_039491883.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EO763_RS00720	169683..169958	-	276	WP_161527778.1	type II toxin-antitoxin system HicA family toxin	Toxin
EO763_RS00725	170195..170704	-	510	WP_161527779.1	cell-envelope stress modulator CpxP	-
EO763_RS00730	170858..171556	+	699	WP_010308725.1	envelope stress response regulator transcription factor CpxR	-
EO763_RS00735	171553..172923	+	1371	WP_161527780.1	envelope stress sensor histidine kinase CpxA	-
EO763_RS00740	173051..173983	-	933	WP_161527781.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-85)

Antitoxin

• Uncharacterised protein family HicB (61-113)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10052.67 Da
• Isoelectric Point: 11.4041

>T116993 WP_161527778.1 NZ_CP034938:c169958-169683 [Pectobacterium odoriferum]
MRGKIASLRKKQRETLNQIFKTPVLSGVKWSSIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP

Nucleotide

• Length: 276 bp

>T116993 NZ_CP034938:c169958-169683 [Pectobacterium odoriferum]
ATGCGGGGAAAAATAGCCAGCCTACGAAAGAAGCAGCGGGAAACGCTGAACCAAATTTTCAAAACACCAGTACTTTCAGG
TGTTAAATGGTCGAGTATTGAGTCACTCGTTACTGCGTTAGGCGGTGAAATTAAGGAAGGTAGCGGGTCACGAGTGCGAT
TTTTATTGAACGGGAGTATCGCCCGATTCCATCGTCCTCATCCGTCACCGGATACTGATAAAGGTGCACTGGTTAGCCTG
CGTGAATGGCTGGAAAGTATAGGAGTAAAACCATGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13518.34 Da
• Isoelectric Point: 4.4969

>AT116993 WP_039491883.1 NZ_CP034938:c169686-169324 [Pectobacterium odoriferum]
MTKALNTPNTMVISGQPAIISYVPEMGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLSEHLKQA

Nucleotide

• Length: 363 bp

>AT116993 NZ_CP034938:c169686-169324 [Pectobacterium odoriferum]
ATGACGAAAGCACTCAACACACCAAATACGATGGTTATTTCTGGACAACCGGCCATTATCAGTTACGTACCGGAAATGGG
TATGTTTCGTGGCAAGTTTATTGGTTTATCTGGCTACTGTGATTTTGTTGCCGACAGTATTAATGGCTTGAGAAGCGAGG
GTGAAATTTCGCTACGCGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAGCGTGAAGAGAAGGTGAAA
ACATTCACCCTCCGTTACCCTGAATCATTCGGGGAACGATTGACCATTGCGGCCGCTGAACGTCAAATTTCAGTGAATAC
GTTTATTGTTGAAACGCTTAGCGAACACCTGAAACAGGCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A094S1G3