Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1856489..1857015 | Replicon | chromosome |
| Accession | NZ_CP034931 | ||
| Organism | Shigella flexneri strain 2013C-3749 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | EPD86_RS09475 | Protein ID | WP_000323025.1 |
| Coordinates | 1856728..1857015 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | EPD86_RS09470 | Protein ID | WP_000534858.1 |
| Coordinates | 1856489..1856728 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EPD86_RS09435 (1852137) | 1852137..1852340 | + | 204 | WP_000214712.1 | putative selenium delivery protein YdfZ | - |
| EPD86_RS09440 (1852376) | 1852376..1853836 | - | 1461 | WP_000527804.1 | mannitol dehydrogenase family protein | - |
| EPD86_RS09445 (1853925) | 1853925..1854944 | - | 1020 | Protein_1834 | MHS family MFS transporter YdfJ | - |
| EPD86_RS09460 (1855006) | 1855006..1856162 | + | 1157 | Protein_1835 | IS3 family transposase | - |
| EPD86_RS09465 (1856159) | 1856159..1856464 | - | 306 | WP_071818640.1 | hypothetical protein | - |
| EPD86_RS09470 (1856489) | 1856489..1856728 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| EPD86_RS09475 (1856728) | 1856728..1857015 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| EPD86_RS09480 (1857087) | 1857087..1857242 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| EPD86_RS09485 (1857460) | 1857460..1857711 | + | 252 | WP_000980987.1 | protein Rem | - |
| EPD86_RS09490 (1857778) | 1857778..1858056 | + | 279 | Protein_1841 | hypothetical protein | - |
| EPD86_RS09495 (1858058) | 1858058..1859107 | + | 1050 | WP_001265249.1 | DUF968 domain-containing protein | - |
| EPD86_RS09500 (1859120) | 1859120..1859476 | + | 357 | WP_000904111.1 | RusA family crossover junction endodeoxyribonuclease | - |
| EPD86_RS09505 (1859491) | 1859491..1860312 | + | 822 | WP_000762882.1 | antitermination protein | - |
| EPD86_RS09520 (1861233) | 1861233..1861341 | + | 109 | Protein_1845 | DUF3927 family protein | - |
| EPD86_RS09525 (1861622) | 1861622..1861957 | - | 336 | WP_000871291.1 | anti-adapter protein IraM | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1853925..1864316 | 10391 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T116950 WP_000323025.1 NZ_CP034931:1856728-1857015 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T116950 NZ_CP034931:1856728-1857015 [Shigella flexneri]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT116950 WP_000534858.1 NZ_CP034931:1856489-1856728 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT116950 NZ_CP034931:1856489-1856728 [Shigella flexneri]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|