Detailed information of TA system TA116936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 22585..23216
• Replicon: plasmid p3-HV1
• Accession: NZ_CP034922
• Organism: Roseomonas mucosa strain HV1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: RMHFA_RS00105
• Protein ID: WP_099781146.1
• Coordinates: 22585..22995 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2D2H0A1
• Locus tag: RMHFA_RS00110
• Protein ID: WP_027283136.1
• Coordinates: 22992..23216 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RMHFA_RS00100 (RMHFA_05632)	19523..22360	-	2838	WP_099781147.1	SNF2-related protein	-
RMHFA_RS00105 (RMHFA_03203)	22585..22995	-	411	WP_099781146.1	type II toxin-antitoxin system VapC family toxin	Toxin
RMHFA_RS00110 (RMHFA_03204)	22992..23216	-	225	WP_027283136.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
RMHFA_RS00115 (RMHFA_03205)	23329..24447	-	1119	WP_099781145.1	site-specific integrase	-
RMHFA_RS00120 (RMHFA_00086a)	25011..26003	-	993	WP_265838677.1	DNA/RNA non-specific endonuclease	-
RMHFA_RS00125 (RMHFA_05561)	26697..27818	-	1122	WP_126281791.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..51516	51516

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-117)

Antitoxin

• SpoVT-AbrB domain (9-45)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15093.18 Da
• Isoelectric Point: 5.3035

>T116936 WP_099781146.1 NZ_CP034922:c22995-22585 [Roseomonas mucosa]
VTLRYLLDTNLCIRVLRDRPAGLRERFNAEAAALCTSDVVLYELLYGAERSARPAETRREVERFVARLSVLPFDDDAAAH
TAEIRASLERRGGVIGPYDLMIAGQARSRGLVVVTGNLSEFGRVEGLRCEDWLADA

Nucleotide

• Length: 411 bp

>T116936 NZ_CP034922:c22995-22585 [Roseomonas mucosa]
GTGACGCTGCGCTACCTGCTCGACACCAACCTGTGCATCCGGGTGCTGCGCGACCGTCCGGCCGGTCTGCGGGAGCGTTT
CAACGCGGAGGCCGCGGCGCTCTGCACCTCGGACGTGGTGCTCTACGAGCTGCTCTACGGGGCGGAGCGCTCGGCCCGGC
CCGCCGAGACGCGGCGCGAGGTGGAGCGCTTCGTGGCCAGGCTGAGCGTGCTGCCCTTCGACGATGACGCGGCGGCGCAC
ACGGCCGAGATCCGGGCGAGCCTGGAGCGGCGAGGCGGGGTGATCGGTCCCTACGACCTGATGATCGCGGGCCAGGCGCG
CAGCCGCGGGCTGGTGGTGGTGACGGGCAACCTGAGCGAGTTTGGCCGGGTGGAGGGGCTGCGCTGCGAGGACTGGCTGG
CTGACGCATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8189.41 Da
• Isoelectric Point: 9.1096

>AT116936 WP_027283136.1 NZ_CP034922:c23216-22992 [Roseomonas mucosa]
MPARTTLFLSNRSQAVRLPKGVAFGEGVREVVILRDGPRRVIAPADALWDDFFAGPGLDLGERRQPAMQEREAL

Nucleotide

• Length: 225 bp

>AT116936 NZ_CP034922:c23216-22992 [Roseomonas mucosa]
ATGCCCGCCCGCACGACCCTGTTCCTGTCCAACCGCTCCCAGGCCGTGCGCCTGCCCAAGGGCGTGGCCTTCGGCGAGGG
GGTGCGCGAGGTGGTGATCCTGCGCGACGGCCCCCGCCGCGTCATCGCCCCGGCCGATGCACTGTGGGACGACTTCTTCG
CGGGCCCTGGCCTGGACCTCGGCGAGCGGCGGCAGCCGGCGATGCAGGAACGCGAGGCGCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2D2H0A1