Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1277376..1278865 Replicon chromosome
Accession NZ_CP034910
Organism Ensifer alkalisoli strain YIC4027

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag EKH55_RS23765 Protein ID WP_151613399.1
Coordinates 1277376..1278638 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag EKH55_RS23770 Protein ID WP_151613400.1
Coordinates 1278635..1278865 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKH55_RS23750 1273445..1276303 + 2859 WP_151613398.1 AMP-binding protein -
EKH55_RS23755 1276325..1277149 - 825 Protein_1191 IS630 family transposase -
EKH55_RS23765 1277376..1278638 - 1263 WP_151613399.1 type II toxin-antitoxin system HipA family toxin Toxin
EKH55_RS23770 1278635..1278865 - 231 WP_151613400.1 helix-turn-helix transcriptional regulator Antitoxin
EKH55_RS23775 1279342..1279863 - 522 WP_151613401.1 universal stress protein -
EKH55_RS23780 1279957..1281120 - 1164 WP_151613402.1 2-oxo acid dehydrogenase subunit E2 -
EKH55_RS23785 1281385..1282053 + 669 WP_151613403.1 alpha/beta hydrolase -
EKH55_RS23790 1282058..1282696 + 639 WP_151613404.1 phosphoribosyltransferase -
EKH55_RS23795 1282719..1283624 - 906 WP_151613405.1 homocysteine S-methyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1276766..1277149 383


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(151-386)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45660.28 Da        Isoelectric Point: 5.7232

>T116934 WP_151613399.1 NZ_CP034910:c1278638-1277376 [Ensifer alkalisoli]
MTARVLNVWWNGRIVGQFTQDRHGDIGFAYAEAWIEDESTLPLSASLPKRPERFSRRECRPFFGGLLPEERQRLVAAQAL
GVSPANDFALLDRLGGDVAGALQLLPDNQEPIETGPIADQQPTPLDDAGIVRVLDALPTRPLLAGEEGLRLSLAGAQSKV
PVVLIDGRIALPLPGQATTHILKPPIARFPGTTENEAFAMKLGATIGLDVAPVEPRSAEGRSFLLVERYDRVRDASGAVR
RIHQEDFCQALGVPPETKYASEGGPTFKDCFELLRRVSARPATDVLKLLDAAIFNLVVGNADAHGKNFSILYDDHGPRLA
PLYDLLSTVAYPDLSPKMAMRIGKRATLAEMDADGWQAYAKEAGVGLPLVRRRITHLVDSTAEAVARVLEDISDLFIDSA
RINHVADLIAGRAKLVRLSI

Download         Length: 1263 bp

>T116934 NZ_CP034910:c1278638-1277376 [Ensifer alkalisoli]
ATGACGGCAAGGGTCCTCAACGTCTGGTGGAATGGTCGAATTGTCGGGCAATTCACCCAGGATCGGCACGGCGATATCGG
CTTCGCCTACGCTGAAGCTTGGATCGAAGATGAAAGCACACTTCCGCTTTCAGCCTCCCTACCGAAGCGCCCGGAGCGTT
TTTCCCGTCGTGAATGCAGACCATTTTTTGGCGGCCTACTGCCCGAAGAACGCCAGCGCCTGGTTGCAGCGCAAGCACTG
GGCGTCTCACCTGCAAATGATTTCGCGCTACTCGATCGCTTGGGCGGCGATGTTGCCGGCGCTCTTCAACTCTTGCCGGA
CAATCAGGAACCCATAGAGACCGGACCGATTGCGGACCAGCAGCCGACGCCTCTGGACGACGCAGGAATCGTCCGCGTGC
TAGACGCACTTCCTACGCGGCCGCTACTGGCCGGCGAGGAAGGCTTGAGACTATCGTTGGCCGGCGCCCAATCGAAAGTG
CCAGTTGTTCTGATTGATGGGCGGATCGCGCTTCCGCTTCCCGGCCAGGCGACCACGCACATACTTAAGCCGCCGATCGC
GCGCTTCCCAGGGACGACCGAAAACGAAGCCTTCGCTATGAAGCTCGGCGCCACAATCGGCCTAGACGTCGCCCCCGTCG
AACCGCGGTCTGCGGAAGGACGCTCGTTTCTTCTGGTCGAAAGATATGACCGTGTCCGCGATGCCAGCGGCGCCGTGCGC
CGCATACACCAGGAAGATTTTTGCCAGGCGCTAGGCGTGCCGCCTGAAACGAAATACGCCAGCGAAGGCGGGCCGACATT
CAAGGACTGTTTTGAGCTGTTGCGGCGAGTATCAGCGCGCCCCGCTACAGATGTGTTGAAACTGCTGGACGCCGCAATCT
TCAACCTGGTTGTCGGAAACGCCGACGCCCACGGCAAGAATTTCTCGATCCTCTACGACGATCATGGACCGAGATTGGCT
CCGCTGTACGATCTGCTTTCTACGGTCGCCTATCCAGACCTTTCACCGAAAATGGCCATGAGGATCGGGAAACGTGCCAC
GCTTGCCGAGATGGACGCGGATGGATGGCAGGCTTATGCGAAGGAAGCTGGAGTTGGCTTACCTTTGGTGCGCCGCCGAA
TTACACACTTGGTCGACTCCACCGCTGAGGCCGTAGCGAGAGTATTGGAAGACATCTCAGACCTCTTCATCGATTCCGCT
AGGATAAATCACGTTGCGGACTTGATCGCAGGCCGCGCCAAACTAGTCAGGTTGTCGATTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8138.49 Da        Isoelectric Point: 10.5957

>AT116934 WP_151613400.1 NZ_CP034910:c1278865-1278635 [Ensifer alkalisoli]
MAKRVKTPSDIGALVRSARKEQNLRQDELAGVAGVGLRFIVDLEAGKPTAQIGKVLQVLQTLGCSVDILAPGERRQ

Download         Length: 231 bp

>AT116934 NZ_CP034910:c1278865-1278635 [Ensifer alkalisoli]
ATGGCAAAACGGGTTAAAACTCCATCTGATATCGGCGCGCTGGTCCGAAGTGCTCGCAAGGAGCAAAACTTGCGGCAGGA
CGAGCTTGCAGGCGTTGCTGGCGTCGGGCTCCGGTTCATTGTCGATCTCGAAGCCGGTAAGCCGACAGCTCAGATAGGAA
AAGTGTTGCAGGTTCTGCAAACGCTCGGCTGTTCGGTCGATATTCTGGCTCCTGGTGAGCGCAGACAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References