Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 20362..20993 | Replicon | plasmid p1-AD3 |
Accession | NZ_CP034903 | ||
Organism | Roseomonas mucosa strain AD3 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | RMP42_RS19430 | Protein ID | WP_019463221.1 |
Coordinates | 20362..20772 (-) | Length | 137 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A1S8D2B6 |
Locus tag | RMP42_RS19435 | Protein ID | WP_019463222.1 |
Coordinates | 20769..20993 (-) | Length | 75 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
RMP42_RS19415 (RMP42_03200) | 15379..15939 | - | 561 | WP_019463217.1 | type I-E CRISPR-associated protein Cse2/CasB | - |
RMP42_RS19420 (RMP42_03201) | 15936..17552 | - | 1617 | WP_026033586.1 | type I-E CRISPR-associated protein Cse1/CasA | - |
RMP42_RS19425 (RMP42_03202) | 17629..20304 | - | 2676 | WP_081798677.1 | CRISPR-associated helicase/endonuclease Cas3 | - |
RMP42_RS19430 (RMP42_03203a) | 20362..20772 | - | 411 | WP_019463221.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
RMP42_RS19435 (RMP42_03204a) | 20769..20993 | - | 225 | WP_019463222.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
RMP42_RS19440 (RMP42_03205) | 21106..22230 | - | 1125 | WP_019463223.1 | site-specific integrase | - |
RMP42_RS19445 (RMP42_03206b) | 22227..22634 | - | 408 | WP_019463224.1 | PIN domain-containing protein | - |
RMP42_RS19450 (RMP42_03207b) | 22631..22867 | - | 237 | WP_019463225.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
RMP42_RS19455 (RMP42_03208) | 23150..23923 | + | 774 | WP_026033587.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..385778 | 385778 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 15007.19 Da Isoelectric Point: 6.9320
>T116920 WP_019463221.1 NZ_CP034903:c20772-20362 [Roseomonas mucosa]
VTLRYLLDTNLCIRVLRDRPAGLRGRFNAEAEALCTSDVVLYELLYGAERSARPAEMRREVERFVARLSVLPFDGDAAAH
TAEIRASLERRGAVIGPYDLMIAGQARSRGLVVVTGNLSEFGRVEGLRCEDWLAGA
VTLRYLLDTNLCIRVLRDRPAGLRGRFNAEAEALCTSDVVLYELLYGAERSARPAEMRREVERFVARLSVLPFDGDAAAH
TAEIRASLERRGAVIGPYDLMIAGQARSRGLVVVTGNLSEFGRVEGLRCEDWLAGA
Download Length: 411 bp
>T116920 NZ_CP034903:c20772-20362 [Roseomonas mucosa]
GTGACGCTGCGCTACCTGCTCGACACCAACCTGTGCATCCGGGTGCTGCGCGATCGCCCGGCCGGCCTGCGGGGGCGTTT
CAACGCGGAGGCCGAGGCGCTCTGCACCTCGGACGTGGTGCTCTACGAGCTGCTCTACGGGGCGGAGCGCTCGGCCAGGC
CCGCCGAGATGCGGCGCGAGGTGGAGCGCTTCGTGGCCAGGCTGAGCGTGCTGCCCTTCGACGGTGACGCGGCGGCGCAC
ACGGCCGAGATCCGAGCGAGCCTGGAGCGGCGGGGCGCGGTGATCGGTCCCTACGACCTGATGATCGCCGGCCAGGCGCG
CAGCCGCGGGCTGGTGGTGGTGACGGGCAACCTGAGCGAGTTCGGCCGGGTGGAGGGTCTGCGCTGCGAGGACTGGTTAG
CCGGGGCCTGA
GTGACGCTGCGCTACCTGCTCGACACCAACCTGTGCATCCGGGTGCTGCGCGATCGCCCGGCCGGCCTGCGGGGGCGTTT
CAACGCGGAGGCCGAGGCGCTCTGCACCTCGGACGTGGTGCTCTACGAGCTGCTCTACGGGGCGGAGCGCTCGGCCAGGC
CCGCCGAGATGCGGCGCGAGGTGGAGCGCTTCGTGGCCAGGCTGAGCGTGCTGCCCTTCGACGGTGACGCGGCGGCGCAC
ACGGCCGAGATCCGAGCGAGCCTGGAGCGGCGGGGCGCGGTGATCGGTCCCTACGACCTGATGATCGCCGGCCAGGCGCG
CAGCCGCGGGCTGGTGGTGGTGACGGGCAACCTGAGCGAGTTCGGCCGGGTGGAGGGTCTGCGCTGCGAGGACTGGTTAG
CCGGGGCCTGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8191.34 Da Isoelectric Point: 4.9987
>AT116920 WP_019463222.1 NZ_CP034903:c20993-20769 [Roseomonas mucosa]
MPARTTLFLSNRSQAVRLPKGVAFGEGVREVVILRDGPRRVIAPADALWDDFFAGPGVDLDDRQQPAMQEREAL
MPARTTLFLSNRSQAVRLPKGVAFGEGVREVVILRDGPRRVIAPADALWDDFFAGPGVDLDDRQQPAMQEREAL
Download Length: 225 bp
>AT116920 NZ_CP034903:c20993-20769 [Roseomonas mucosa]
ATGCCCGCCCGCACGACCCTGTTCCTGTCCAACCGCTCCCAGGCCGTGCGCCTGCCCAAGGGCGTGGCCTTCGGCGAGGG
CGTGCGCGAGGTGGTGATCCTGCGCGACGGTCCCCGCCGCGTCATCGCGCCGGCCGACGCGCTGTGGGACGACTTCTTCG
CAGGGCCCGGTGTAGACCTGGATGATCGCCAGCAGCCGGCGATGCAGGAACGCGAGGCACTGTGA
ATGCCCGCCCGCACGACCCTGTTCCTGTCCAACCGCTCCCAGGCCGTGCGCCTGCCCAAGGGCGTGGCCTTCGGCGAGGG
CGTGCGCGAGGTGGTGATCCTGCGCGACGGTCCCCGCCGCGTCATCGCGCCGGCCGACGCGCTGTGGGACGACTTCTTCG
CAGGGCCCGGTGTAGACCTGGATGATCGCCAGCAGCCGGCGATGCAGGAACGCGAGGCACTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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