Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 20362..20993 Replicon plasmid p1-AD3
Accession NZ_CP034903
Organism Roseomonas mucosa strain AD3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag RMP42_RS19430 Protein ID WP_019463221.1
Coordinates 20362..20772 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1S8D2B6
Locus tag RMP42_RS19435 Protein ID WP_019463222.1
Coordinates 20769..20993 (-) Length 75 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RMP42_RS19415 (RMP42_03200) 15379..15939 - 561 WP_019463217.1 type I-E CRISPR-associated protein Cse2/CasB -
RMP42_RS19420 (RMP42_03201) 15936..17552 - 1617 WP_026033586.1 type I-E CRISPR-associated protein Cse1/CasA -
RMP42_RS19425 (RMP42_03202) 17629..20304 - 2676 WP_081798677.1 CRISPR-associated helicase/endonuclease Cas3 -
RMP42_RS19430 (RMP42_03203a) 20362..20772 - 411 WP_019463221.1 type II toxin-antitoxin system VapC family toxin Toxin
RMP42_RS19435 (RMP42_03204a) 20769..20993 - 225 WP_019463222.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
RMP42_RS19440 (RMP42_03205) 21106..22230 - 1125 WP_019463223.1 site-specific integrase -
RMP42_RS19445 (RMP42_03206b) 22227..22634 - 408 WP_019463224.1 PIN domain-containing protein -
RMP42_RS19450 (RMP42_03207b) 22631..22867 - 237 WP_019463225.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
RMP42_RS19455 (RMP42_03208) 23150..23923 + 774 WP_026033587.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..385778 385778


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-117)

Antitoxin

(9-45)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 15007.19 Da        Isoelectric Point: 6.9320

>T116920 WP_019463221.1 NZ_CP034903:c20772-20362 [Roseomonas mucosa]
VTLRYLLDTNLCIRVLRDRPAGLRGRFNAEAEALCTSDVVLYELLYGAERSARPAEMRREVERFVARLSVLPFDGDAAAH
TAEIRASLERRGAVIGPYDLMIAGQARSRGLVVVTGNLSEFGRVEGLRCEDWLAGA

Download         Length: 411 bp

>T116920 NZ_CP034903:c20772-20362 [Roseomonas mucosa]
GTGACGCTGCGCTACCTGCTCGACACCAACCTGTGCATCCGGGTGCTGCGCGATCGCCCGGCCGGCCTGCGGGGGCGTTT
CAACGCGGAGGCCGAGGCGCTCTGCACCTCGGACGTGGTGCTCTACGAGCTGCTCTACGGGGCGGAGCGCTCGGCCAGGC
CCGCCGAGATGCGGCGCGAGGTGGAGCGCTTCGTGGCCAGGCTGAGCGTGCTGCCCTTCGACGGTGACGCGGCGGCGCAC
ACGGCCGAGATCCGAGCGAGCCTGGAGCGGCGGGGCGCGGTGATCGGTCCCTACGACCTGATGATCGCCGGCCAGGCGCG
CAGCCGCGGGCTGGTGGTGGTGACGGGCAACCTGAGCGAGTTCGGCCGGGTGGAGGGTCTGCGCTGCGAGGACTGGTTAG
CCGGGGCCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8191.34 Da        Isoelectric Point: 4.9987

>AT116920 WP_019463222.1 NZ_CP034903:c20993-20769 [Roseomonas mucosa]
MPARTTLFLSNRSQAVRLPKGVAFGEGVREVVILRDGPRRVIAPADALWDDFFAGPGVDLDDRQQPAMQEREAL

Download         Length: 225 bp

>AT116920 NZ_CP034903:c20993-20769 [Roseomonas mucosa]
ATGCCCGCCCGCACGACCCTGTTCCTGTCCAACCGCTCCCAGGCCGTGCGCCTGCCCAAGGGCGTGGCCTTCGGCGAGGG
CGTGCGCGAGGTGGTGATCCTGCGCGACGGTCCCCGCCGCGTCATCGCGCCGGCCGACGCGCTGTGGGACGACTTCTTCG
CAGGGCCCGGTGTAGACCTGGATGATCGCCAGCAGCCGGCGATGCAGGAACGCGAGGCACTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A1S8D2B6

References